FOXOs转录因子在心脏疾病治疗中的研究进展  

FOXOs: potential targets for treatment of heart diseases

作　　者：李晓霞[1] 吕俊利 张春莹 郭会彩[1] LI Xiao-xia;LYU Jun-li;ZHANG Chun-ying;GUO Hui-cai(Dept of Toxicology,Hebei Medical University,Hebei Key Lab of Environemnt and Human Health,Shijiazhuang050017,China)

机构地区：[1]河北医科大学卫生毒理学教研室河北省环境与人群健康重点实验室,河北石家庄050017

出　　处：《中国药理学通报》2019年第3期306-309,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81473292);河北省自然科学基金资助项目(No B2018206283)

摘　　要：心脏疾病发病率高、死亡率高,严重影响人类健康,其中以缺血性心脏病和心肌肥厚最为常见。转录因子FOXOs可以通过对抗氧化应激、促进细胞凋亡和自噬等作用保护心脏组织,在心脏疾病的治疗中发挥着重要作用。该文综述了FOXOs在心脏疾病中的作用以及信号通路,FOXOs作为心脏疾病治疗的潜在靶点,为心脏疾病的治疗提供新的思路。The high incidence and mortality of heart disease seriously affect human health.Among them,ischemic heart disease and myocardial hypertrophy are the most common.The transcription factor FOXOs can protect heart tissue by fighting oxidative stress and promoting apoptosis and autophagy,playing an important role in the treatment of heart disease.This article reviews the role of FOXOs in heart disease and signaling pathways.for the treatment of heart disease,FOXOs,as a potential target,provide new ideas for the treatment of heart disease.

关 键 词：FOXOs FOXO1 FOXO3 信号通路 缺血性心肌病 心脏肥厚 

分 类 号：R-05[医药卫生] R329.24