腹腔镜肝癌切除术对原发性肝癌患者血清恶性生物学指标及术后康复的影响  

Effect of Laparoscopic Hepatectomy on the Serum Malignant Biological Indexes and Postoperative Rehabilitation of Patients with Primary Liver Cancer

作　　者：邓天芝[1] 陈晓梅[2] 龙洪航[1] Deng Tianzhi;Chen Xiaomei;Long Honghang(Department of Hepatological Surgery,The First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China;Outpatient Department,The First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China)

机构地区：[1]成都医学院第一附属医院肝胆胰外科,成都610500 [2]成都医学院第一附属医院门诊部,成都610500

出　　处：《成都医学院学报》2019年第1期88-92,共5页Journal of Chengdu Medical College

摘　　要：目的探讨腹腔镜肝癌切除术对原发性肝癌患者血清恶性生物学指标及术后康复的影响。方法以成都医学院第一附属医院2015年1月至2017年1月期间收治的90例原发性肝癌患者进行研究,随机分为试验组和对照组,每组45例,试验组采用腹腔镜下肝癌切除术治疗,对照组采用传统开腹手术治疗。对两组患者手术情况、术后康复及并发症等进行观察比较,对两组患者治疗前后免疫功能指标、血清恶性生物学指标及肝功能指标进行对比。结果试验组手术进行及术后康复的各项指标均优于对照组(P<0.05)。试验组术后并发症发生率为4.44%,低于对照组的20.00%(P<0.05)。两组患者术后CD^(3+)、CD^(4+)细胞阳性率、CD^(4+)/CD^(8+)比值均低于术前,且试验组高于对照组,CD^(8+)细胞阳性率高于术前,且试验组低于对照组(P<0.05)。两组患者术后谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBILI)、直接胆红素(DBILI)水平均高于术前,且试验组低于对照组(P<0.05)。两组患者术后血管内皮生长因子(VEGF)、酸性成纤维细胞生长因子(aFGF)、碱性成纤维细胞生长因子(bFGF)水平均低于术前,且试验组低于对照组(P<0.05)。结论原发性肝癌患者实施腹腔镜下肝癌切除术能够缩短患者术后康复时间,提高手术治疗的安全性,对患者的免疫功能、肝功能影响较小,且能进一步降低患者血清恶性生物学指标水平,临床应用价值较高,值得进一步推广应用。Objective To study the effect of laparoscopic hepatectomy on the serum malignant biological indexes and postoperative rehabilitation of patients with primary liver cancer.Methods A total of 90 cases with primary liver cancer admitted into The First Affiliated Hospital of Chengdu Medical College from January of 2015 to January of 2017 were selected as the research objects and randomly divided into the experiment group and control group,and each group consisted of 45 cases.The experiment group was treated with laparoscopic hepatectomy,while the control group was treated with the traditional open surgery.The statuses of operation and postoperative rehabilitation and the complications in the two groups were observed and compared.The immune function indexes,serum malignant biological indexes and liver function indexes before and after treatment in the two groups were compared.Results All the indexes of the operation and postoperative rehabilitation in the experiment group were significantly better than those in the control group(P<0.05).The incidence of postoperative complications in the experiment group was 4.44% and it was significantly lower than that in the control group which was 20.00%(P<0.05).The positive rate of CD^3+ and CD^4+ and the ratio of CD^4+/CD^8+ were all lower after operation than before operation in both groups,and those in the experiment group were higher than those in the control group.The positive rate of CD^8+ was higher after operation than before operation in both groups,and that of the experiment group was significantly lower than that of the control group(P<0.05).The levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBILI),direct bilirubin(DBILI)were higher after operation than before operation in both groups,and those of the experiment group was significantly lower than those of the control group(P<0.05).The levels of vascular endothelial growth factor(VEGF),acidic fibroblast growth factor(aFGF)and basic fibroblast growth factor(bFGF)were all lower aft

关 键 词：原发性肝癌 腹腔镜手术 免疫功能 肝功能 恶性生物学指标 

分 类 号：R735.7[医药卫生—肿瘤]