低剂量地西他滨联合半量CAG治疗老年急性髓系白血病的临床研究  

Clinical Study of Low-dose Dicetabine Combined with Half-dose CAG in the Treatment of Elderly Patients with Acute Myeloid Leukemia

作　　者：杨昆 马春蓉[1] 何旭[1] 胡银山 何秋连[1] Yang Kun;Ma Chunrong;He Xu;Hu Yinshan;He Qiulian(The Second Affiliated Hospital of North Sichuan Medical College & Nanchong Central Hospital,Nanchong 637000,China)

机构地区：[1]川北医学院第二临床医学院.南充市中心医院,南充637000

出　　处：《成都医学院学报》2019年第1期103-106,共4页Journal of Chengdu Medical College

摘　　要：目的对比低剂量国产地西他滨联合半量CAG方案与CAG方案治疗老年急性髓系白血病的疗效及安全性。方法收集2015年2月至2018年6月在川北医学院第二临床医学院·南充市中心医院诊治的老年急性髓系白血病42例,其中22例作为试验组给予低剂量地西他滨联合半量CAG方案,20例作为对照组给予标准剂量CAG方案,比较两组患者的疗效及不良反应。结果试验组的总有效率(86.4%)高于对照组(55.0%),差异有统计学意义(P<0.05)。两组不良反应的表现及发生率相似,差异无统计学意义(P> 0.05)。结论低剂量国产地西他滨+半量CAG方案的总缓解率优于CAG方案,且不增加化疗相关风险,可作为老年急性髓系白血病的一线治疗方案。Objective To compare the clinical efficacy and safety between the regimen of the low-dose decitabine combined with half-dose CAG and the CAG regimen in the treatment of elderly patients with acute myeloid leukemia(AML).Methods A total of 42 cases of elderly patients with AML treated in Nanchong Central Hospital from February of 2015 to June of 2018 were selected in the study.The expereiment group with 22 patients were treated with the regimen of low-dose decitabine combined with half-dose CAG,and the control group with the other 20 patients received the CAG regimen.Results The overall effective rate in the experiement group(81.8%)was significantly higher than that in control group(55.0%)(P<0.05).The manifestations and incidence of adverse reactions were not significantly different between both group(P>0.05).Conclusion The overall effective rate of the regimen of low-dose decitabine combined with half-dose CAG is higher than that of the CAG regimen without increasing the risks associated with chemotherapy,so it can be used as the first-line treatment regimen for elderly patients with AML.

关 键 词：急性髓系白血病 老年 地西他滨 CAG 

分 类 号：R733.71[医药卫生—肿瘤]