RhoA蛋白及驱动蛋白KIF2A与卵巢癌临床病理特征的相关性研究  

Clinicopathological significance of KIF2A and RhoA in ovarian cancer

作　　者：管文华 项锋钢[1] Wen-hua Guan;Feng-gang Xiang(Department of Pathology,School of Basic Medicine,Qingdao University,Qingdao,Shandong 266021,China)

机构地区：[1]青岛大学基础医学院病理学系,山东青岛266021

出　　处：《中国现代医学杂志》2019年第5期29-34,共6页China Journal of Modern Medicine

摘　　要：目的探讨RhoA蛋白和驱动蛋白KIF2A在卵巢癌组织中的表达及临床意义。方法采用免疫组织化学法检测正常卵巢组织20例、卵巢上皮良性肿瘤25例以及卵巢癌45例中的KIF2A、RhoA蛋白表达,观察RhoA、KIF2A在3组中的表达情况,分析其表达与临床病理特征的关系及两者间的相关性。结果与卵巢上皮良性肿瘤、正常卵巢组织比较,卵巢癌组织中KIF2A、RhoA蛋白的阳性表达率更高(P <0.05);正常卵巢组织与卵巢上皮良性肿瘤间的表达比较差异无统计学意义(P>0.05)。卵巢癌分期、淋巴结转移与KIF2A蛋白的表达密切相关(P <0.05);与组织学分级、病理类型以及年龄无关(P>0.05)。淋巴结转移、组织学分级与RhoA蛋白表达密切相关(P<0.05);与病理类型、临床分期以及年龄无关(P>0.05)。KIF2A、RhoA在卵巢癌中的表达呈正相关(r=0.801,P <0.05)。结论 KIF2A、RhoA蛋白在卵巢癌组织中高表达;两者可能共同参与卵巢癌的发生、发展过程,为临床靶向治疗卵巢癌提供新思路。Objective To investigate the clinical significance of Kif2A and RhoA in ovarian cancer.Methods Totally 20 cases of normal ovarian tissues,25 cases of benign epithelial ovarian tumors,and 45 cases of ovarian cancer were involved in this study.Expression of Kif2A and RhoA protein was identified by immunohistochemistry.Association between Kif2A/RhoA and clinicopathological features was analyzed.Results The positive rates of Kif2A and RhoA protein expression in ovarian cancer tissues were increased compared with those in ovarian epithelial benign tumors and normal ovarian tissues(P<0.05),while no significant difference in expression of Kif2A and RhoA between normal ovarian tissues and benign epithelial ovarian tumors was confirmed(P>0.05).Expression of Kif2A was closely correlated to ovarian cancer staging and lymph node metastasis(P<0.05).RhoA was closely associated with lymph node metastasis and histological grading(P<0.05).The expression of Kif2A was positively correlated to expression of RhoA in ovarian cancer(r=0.801,P<0.05).Conclusions High expression of Kif2A and RhoA proteins in ovarian cancer tissues may be involved in the development of ovarian cancer.

关 键 词：卵巢肿瘤 驱动蛋白 RhoA/单体GTP结合蛋白质类 免疫组织化学 

分 类 号：R737.31[医药卫生—肿瘤]