鳖甲煎丸对急性缺血性脑卒中患者的疗效、颈动脉粥样硬化斑块形成及血清炎症因子水平的影响  

Effect of Biejia pills on efficacy,formation of carotid atherosclerotic plaque,and serum inflammatory factors levels in patients with acute cerebral ischemic stroke

作　　者：张文富[1] 肖友生[2] 黄晶晶[3] 林才志[1] 於丽丽[1] 潘哲[1] ZHANG Wen-fu;XIAO You-sheng;HAUNG Jing-jing;LIN Cai-zhi;YU Li-li;PAN Zhe(Internal Medicine Department of Integrated Traditional Chinese and Western Medicine,Ren′ai Branch of the First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530001,China;Department of Neurology,the First Affiliated Hospital ofGuangxi Medical University,Nanning 530021,China;Department of Spleen,Stomach and Liver Diseases,Xianhu Branch of the First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530200,China)

机构地区：[1]广西中医药大学第一附属医院仁爱分院中西医结合内科,南宁市530001 [2]广西医科大学第一附属医院神经内科,南宁市530021 [3]广西中医药大学第一附属医院仙葫院区脾胃肝病科,南宁市530200

出　　处：《广西医学》2019年第3期281-284,共4页Guangxi Medical Journal

基　　金：国家自然科学基金(81403382;81760845);广西自然科学基金(2015GXNSFBA139128)

摘　　要：目的探讨鳖甲煎丸对急性缺血性脑卒中患者的疗效、颈动脉粥样硬化斑块形成及血清炎症因子水平的影响。方法将120例急性缺血性脑卒中患者随机分为鳖甲煎丸组和常规治疗组,每组60例。两组均给予常规治疗,鳖甲煎丸组同时给予鳖甲煎丸口服治疗。比较两组患者治疗后神经功能的恢复情况,以及治疗前后血清炎症因子水平、颈动脉粥样硬化斑块指标。观察两组治疗期间不良反应的发生情况。结果治疗后,鳖甲煎丸组疗效确切者及预后良好者的比例均高于常规治疗组(均P <0. 05);两组血清C反应蛋白和肿瘤坏死因子α水平、粥样硬化斑块总面积和不稳定斑块数目较治疗前下降(均P <0. 05),且鳖甲煎丸组以上指标均低于常规治疗组(均P <0. 05)。两组不良反应发生率差异无统计学意义(P> 0. 05)。结论在常规治疗基础上应用鳖甲煎丸可更好地促进急性缺血性脑卒中患者神经功能的恢复,改善短期预后,可更有效地降低急性期血清炎症因子水平,并在一定程度上减轻患者的颈动脉粥样硬化程度。Objective To explore effect of Biejia pills on the efficacy,formation of carotid atherosclerotic plaque and serum inflammatory factors levels in patients with acute cerebral ischemic stroke.Methods A total of 120 patients with acute ischemic stroke were randomly divided into Biejia Pills group or conventional treatment group,with 60 cases in each group.Both groups received conventional treatment,and moreover,the Biejia Pills group was orally administered with Biejia pills.The recovery of neurological function after treatment,and serum inflammatory factors levels and indices of carotid atherosclerotic plaque before and after treatment were compared between the two groups.The incidence of adverse reactions during treatment was observed in both groups.Results After treatment,the proportions of cases with definite efficacy and good prognosis were higher in the Biejia Pills group than in the conventional treatment group(all P <0.05);the C-reactive protein and tumor necrosis factor α levels,total plaque area and unstable plaque number decreased in both groups(all P <0.05),with the indices above lower in the Biejia Pills group than in the conventional treatment group(all P <0.05).There was no statistical difference in the incidence of adverse reactions between the two groups( P >0.05).Conclusion On the basis of conventional therapy,Biejia pills can promote the improvement of neurological function and short-term prognosis better,reduce serum inflammatory factors level more effectively during the acute stage,and alleviate the degree of carotid atherosclerosis to some degree in patients with acute cerebral ischemic stroke.

关 键 词：急性缺血性脑卒中 鳖甲煎丸 疗效 颈动脉粥样硬化斑块 炎症因子 

分 类 号：R743.3[医药卫生—神经病学与精神病学]