核糖体DNA转录的表观调控与肿瘤发生  

The epigenetic regulation of ribosomal DNA and tumorigenesis

作　　者：程香荣 胡兴琳 姜琦 黄星卫 王楠[1] 雷蕾[1] Xiangrong Cheng;Xinglin Hu;Qi Jiang;Xingwei Huang;Nan Wang;Lei Lei(Department of Histology and Embryology,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学组织学与胚胎学教研室,哈尔滨150081

出　　处：《遗传》2019年第3期185-192,共8页Hereditas（Beijing)

基　　金：国家自然科学基金项目(编号:31671545)资助~~

摘　　要：近年来,表观遗传机制的研究结果提示核糖体DNA (rDNA)表观调控机制的缺陷可能诱导肿瘤发生。ATRX/DAXX复合物通过介导H3.3的H3K9me3修饰,建立和维持rDNA转录沉默。ATRX/DAXX基因在部分肿瘤中经常发生突变,可能刺激rDNA转录而促进肿瘤发生发展。本文主要阐述rDNA转录表达异常对肿瘤发生的促进作用,介绍rDNA基因转录的表观遗传调控机制,以期为针对rDNA转录调控机制的药物研发提供新的理论支持。Recent research in epigenetics suggests that defects in epigenetic regulation of ribosomal DNA(rDNA)transcription may contribute to tumorigenesis.ATRX/DAXX complex is involved in the establishment and maintenance of the silence of the rDNA gene through H3K9me3 modification at histone variant H3.3.The ATRX/DAXX-related genes are frequently mutated in some types of tumors,which may increase rDNA transcription and promote cancer development and progression.In this review,we focus on the mechanism that abnormal transcription of rDNA potentially influences tumorigenesis.We also summarize the epigenetic regulatory mechanism of rDNA transcription,which may provide new theoretical support for drug development based on rDNA transcriptional regulation.

关 键 词：RDNA 表观调控 H3.3 ATRX/DAXX 肿瘤发生 

分 类 号：R730.2[医药卫生—肿瘤]