多潘立酮胶囊联合替普瑞酮治疗慢性萎缩性胃炎的临床研究  

Clinical Observation of Doperridone Combined with Tipurone for Treatment of Chronic Atrophic Gastritis

作　　者：缪小玉[1] 肖嘉新[1] MIAO Xiao-yu;XIAO Jia-xin(Department of Cadre Special Clinic Section 2,Fujian Provincial Hospital,Fuzhou,350003,China)

机构地区：[1]福建省立医院干部特诊二科,福州350003

出　　处：《黑龙江医学》2019年第2期117-119,共3页Heilongjiang Medical Journal

摘　　要：目的探讨多潘立酮胶囊联合替普瑞酮治疗慢性萎缩性胃炎(chronic atrophic gastritis,CAG)的临床疗效及安全性。方法选择2015年1月—2017年6月福建省立医院收治的93例CAG患者,按随机数字表法随机分为对照组与治疗组,对照组46例,治疗组47例。对照组给予多潘立酮治疗,治疗组在对照组治疗的基础上联合替普瑞酮治疗,两组均连续治疗4周。治疗后进行临床疗效评价。检测并比较两组治疗前后血清白细胞介素-6(IL-6)、C反应蛋白(CRP)及肿瘤坏死因子-α(TNF-α)水平,以及两组治疗过程中不良反应的发生情况。结果治疗组的总有效率为93.62%(44/47),对照组为73.91%(34/46),两组比较差异有统计学意义(χ~2=6.672,P=0.010)。两组治疗后血清IL-6、CRP及TNF-α水平均明显小于治疗前,且治疗组血清IL-6、CRP及TNF-α水平变化均优于对照组,差异有统计学意义(P<0.05)。两组治疗过程中不良反应发生率比较,差异无统计学意义(χ~2=0.498,P=0.481)。结论在常规治疗的基础上应用多潘立酮胶囊联合替普瑞酮治疗CAG的临床疗效显著,抗炎作用较强,且安全性较好,值得在临床上推广应用。Objective To explore clinical efficacy and safety of doperridone combined with tipurone for treatment of chronic atrophic gastritis(CAG). Methods According to the random table method,93 patients with CAG in the hospital from January,2015 to June,2017 were divided into control group(n=46)and treatment group(n=47). Patients of control group were treated with doperridone,while treatment group was treated with doperridone and tipurone. The two groups were treated for 4 weeks. Clinical curative effect was evaluated after treatment. The level of serum IL-6,CRP and TNF-α of the two groups was detected and compared before and after treatment. The occurrence of adverse reactions in the two groups was recorded and compared. Results Total effective rate of treatment group was 93.62%(44/47)and control group was 73.91%(34/46). The difference was statistically significant(χ2=6.672, P= 0.010). After treatment,the level of serum IL-6,CRP and TNF-α of the two groups was significantly lower than that before treatment,and that of the treatment group was significantly better than that in the control group(P<0.05). There was no significantly difference of the adverse reaction rates of the two groups during treatment(χ2=0.498,P=0.481). Conclusion On the basis of conventional therapy,the clinical efficacy of doperridone combined with tipurone in the treatment of CAG was significant,the anti-inflammatory effect was stronger,and the safety was higher. It was worth popularizing in clinical application.

关 键 词：慢性萎缩性胃炎 多潘立酮 替普瑞酮 疗效 安全性 

分 类 号：R573.32[医药卫生—消化系统]