脑钠肽与急性脑梗死及脑梗死静脉溶栓的相关性研究进展  

Advances in research on the relationship between brain natriuretic peptide and acute cerebral infarction and venous thrombolysis

作　　者：袁佳欣 陈琦 窦连伟 刘宏[2] 刘杰[2] 任超 王晓彤[1] YUAN Jiaxin;CHEN Qi;DOU Lianwei;LIU Hong;LIU Jie;REN Chao;WANG Xiaotong(Department of Neurology,Yantai Yuding Hospital,Qingdao University,Yantai 264000,China;Department of Neurological Care,Yantai Yuhuangding Hospital,Qingdao University,Yantai 264000,China)

机构地区：[1]青岛大学附属烟台毓璜顶医院神经内科,山东烟台264000 [2]青岛大学附属烟台毓璜顶医院神经监护室,山东烟台264000

出　　处：《中国实用神经疾病杂志》2019年第1期107-111,共5页Chinese Journal of Practical Nervous Diseases

基　　金：烟台市科技计划项目(编号:2018SFGY091);烟台市科技计划项目(编号:2017WS105);山东省医药卫生科技发展计划项目(编号:2017WSA388);烟台毓璜顶医院院内科研启动基金项目(编号:KJ0160)

摘　　要：脑钠肽(brain natriuretic peptide,BNP)是一种神经激素,具有调节血容量、降低体循环阻力、抑制RAAS系统和交感神经作用,参与血压、血容量及水盐平衡调节的作用。急性缺血性脑卒中是最常见的卒中类型,有较高的致死、致残率,rt-PA静脉溶栓是目前恢复脑灌注的最主要措施。BNP作为心血管疾病发生发展过程中重要的预测因子,已被广泛认可,而本文就BNP在脑梗死、静脉溶栓患者中的变化以及BNP在脑梗死及静脉溶栓治疗预后的预测功能方面做一综述。Brain natriuretic peptide(BNP)is a neurohormone that regulates blood volume,reduces systemic resistance,inhibits RAAS system and sympathetic nerves,and participates in the regulation of blood pressure,blood volume and water-salt balance.Acute ischemic stroke is the most common type of stroke with high mortality and disability.rt-PA intravenous thrombolysis is the most important measure to restore cerebral perfusion.BNP has been widely recognized as an important predictor of cardiovascular disease development and development,and this article reviews the changes of BNP in patients with cerebral infarction and its predictive function of venous thrombolysis after cerebral infarction and cerebral infarction.

关 键 词：脑钠肽 急性脑梗死 静脉溶栓 重组组织型纤溶酶原激活剂 脑血管病 

分 类 号：R743.33[医药卫生—神经病学与精神病学]