3D打印技术在牙周组织再生支架制备中的应用  

Application of 3D printing technology in preparation of scaffolds for periodontal tissue regeneration

作　　者：许雄程 钟泉[1] 骆凯[1] XU Xiongcheng;ZHONG Quan;LUO Kai(Stomatological Hospital of Fujian Medical University,Fuzhou 350002,China)

机构地区：[1]福建医科大学附属口腔医院,福建福州350002

出　　处：《口腔疾病防治》2019年第3期189-193,共5页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：福建省自然科学基金项目(2017J01805;2017J01522);福建省科技创新联合资金项目(2016Y9023)

摘　　要：如何获得理想的牙周组织的再生修复依然是当前牙周炎临床治疗的挑战。3D打印技术是基于计算机辅助设计,经逐层叠加制作特定三维形态的材料,现已应用于牙周组织再生治疗,为实现理想的牙周再生带来希望。本文拟就3D打印技术在牙周组织再生领域中的应用进行综述。文献复习结果表明,3D打印技术可预先通过计算机软件设计三维结构,生产出具有特定三维结构的材料;3D打印技术主要包括选择性激光烧结、选择性激光熔化、挤压成形打印和3D生物打印;当前通过3D打印技术制备的支架材料有陶瓷材料、高分子材料和金属;高分子材料因其可调节性大而被广泛研究,而3D打印的个性化钛网已被应用于临床;利用3D打印技术制备的多相材料在动物试验上已可实现牙周组织再生,但应用于牙周炎患者疗效欠佳。3D打印牙周组织再生复合支架有待于进一步的研究。How to obtain ideal regeneration of periodontal tissue remains a challenge in the clinical treatment of periodontitis.Three-dimensional printing technology is based on computer-aided design,which produces materials with specific 3 D shapes by layer-by-layer superposition,and has been applied to periodontal tissue regeneration therapy,this method offers hope to achieve ideal periodontal regeneration.This article reviews the application of 3 D printing technology in the field of periodontal tissue regeneration.The literature review results show that 3 D printing technology can design three-dimensional structures using computer software in advance and produce materials with specific three-dimensional structures.3 D printing technology mainly includes selective laser sintering,selective laser melting,extrusion forming printing and 3 D bioprinting.At present,the support materials prepared by 3 D printing technology include ceramic materials,polymer materials and metals.Submaterials have been extensively studied given their high adjustability,and 3 D-printed personalized titanium mesh has been applied in the clinic.Multiphase materials prepared by 3 Dprinting technology can regenerate periodontal tissue in animal experiments,but the effect is not good in patients with periodontitis.In addition,3 D printing of composite scaffolds for periodontal tissue regeneration need to be further studied.

关 键 词：牙周炎 3D打印 牙周组织再生 支架材料 选择性激光烧结 选择性激光熔化 

分 类 号：R781.4[医药卫生—口腔医学]