细胞治疗帕金森病的研究进展  

Cell therapy for Parkinson's disease

作　　者：刘馨遥 董婕[1] 乐卫东[1] LIU Xinyao;DONG Jie;LE Weidong(Liaoning Provincial Center for Clinical Research on Neurological Diseases & Liaoning ProvincialKey Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases & The First Affiliated Hospital, Dalian Medical University, Dalian Liaoning 116021, China)

机构地区：[1]大连医科大学附属第一医院,辽宁省神经系统疾病临床医学研究中心,辽宁省神经系统重大疾病发病机制研究重点实验室,辽宁大连116021

出　　处：《转化医学杂志》2018年第6期334-337,共4页Translational Medicine Journal

基　　金：国家自然科学基金项目(81430021,81771521)

摘　　要：目前帕金森病(Parkinson’s disease,PD)的治疗主要以症状控制的药物治疗为主,但仍缺乏有效的根治措施。细胞治疗可通过神经移植来替代和修复PD中丢失或损伤的多巴胺神经元,从而改善或逆转疾病的进程,为PD的治疗带来了新的希望。作者主要介绍PD细胞治疗的背景,并对目前不同细胞来源的治疗进展和利弊进行综述。Pharmacotherapy is currently the first line symptomatic treatment of Parkinson ’ s disease (PD), but we still lack the effective way to cure PD nowadays. Cell therapy for PD aims to replace and repair the lost or injured dopaminergic neurons in PD, which in turn leads to the amelioration or reversion of the pathological progression of PD. Cell therapy provides us a prospect for future PD management. This paper introduced the background of cell therapy for PD, and reviewed the pros and cons and new research development of cell therapy with different cell origins.

关 键 词：帕金森病 干细胞 细胞移植 

分 类 号：R742.5[医药卫生—神经病学与精神病学]