Tim-3/Galectin-9在原发性肝癌中的表达变化及临床意义探讨  

Expression and clinical significance of Tim-3/Galectin-9 in primary liver cancer

作　　者：兰勇[1] 陈明[1] 邢人伟[1] LAN Yong;CHEN Ming;XING Renwei(Department of Hepatobiliary and Pancreatic Surgery,Taizhou Municipal Hospital in Zhejiang Province,Taizhou 318000,China)

机构地区：[1]浙江省台州市立医院肝胆胰外科,浙江台州318000

出　　处：《中国现代医生》2019年第4期49-53,共5页China Modern Doctor

基　　金：浙江省医药卫生科技项目(2018KY902)

摘　　要：目的探讨T细胞免疫球蛋白粘蛋白-3(T cell immunoglobulin mucin-3,Tim-3)/半乳糖凝集素-9(Galectin-9)在原发性肝癌(primary liver cancer,PLC)中的表达变化及临床意义。方法回顾性分析2014年6月～2016年6月收治的110例接受根治性切除术的PLC患者的临床资料。检测并对比肝癌组织及癌旁组织中Tim-3、Galectin-9表达情况,统计Tim-3、Galectin-9不同表达情况时患者病理参数、随访1年内复发和死亡情况。结果肝癌组织中Tim-3阳性表达率显著高于癌旁组织(P<0.05),肝癌组织中Galectin-9阳性表达率显著低于癌旁组织(P<0.05);Tim-3、Galectin-9阳性组与阴性组性别、年龄、肝硬化、血清甲胎蛋白(alpha-fetoprotein,AFP)、乙型肝炎表面抗原(hepatitis B surface antigen,HBsAg)、病理分型、TNM分期患者构成比比较差异不显著(P>0.05),Tim-3阳性组肿瘤直径≥5 cm、多发病灶、血管侵犯、无肿瘤包膜患者构成比显著高于阴性组(P<0.05),Galectin-9阳性组肿瘤直径≥5 cm、多发病灶、血管侵犯、无肿瘤包膜患者构成比显著低于阴性组(P<0.05);术后1年内复发和死亡患者中Tim-3阳性表达率显著高于未复发和存活患者(P<0.05);复发和死亡患者中Galectin-9表达率显著低于未复发和存活患者(P<0.05)。结论 Tim-3的高表达、Galectin-9低表达与PLC多种病理学特征有关,且复发与未复发、死亡与存活患者中Tim-3、Galectin-9蛋白表达存在差异,可能成为临床中评估PLC患者预后的重要指标之一。Objective To investigate the expression changes and clinical significance of T cell immunoglobulin mucin-3(Tim-3)/Galectin-9 in primary liver cancer(PLC).Methods The clinical data of 110 PLC patients who underwent radical resection from June 2014 to June 2016 were retrospectively analyzed.The expressions of Tim-3 and Galectin-9 in liver cancer tissues and adjacent tissues were detected and compared.The pathological parameters,the recurrence and death within 1 year of follow-up of patients with different expressions of Tim-3 and Galectin-9 were analyzed.Results The positive expression rate of Tim-3 in liver cancer tissue was significantly higher than that in adjacent tissues(P<0.05).The positive expression rate of Galectin-9 in liver cancer tissue was significantly lower than that in adjacent tissue(P<0.05).There was no significant difference in gender,age,liver cirrhosis,serum alpha-fetoprotein(AFP),hepatitis B surface antigen(HBsAg),pathological type,and the composition ratios of TNM staging in Tim-3 and Galectin-9 positive and negative groups(P>0.05).The composition ratio of tumor diameter≥5 cm,multiple lesions,vascular invasion,no tumor capsules in Tim-3 positive group was significantly higher than that in the negative group(P<0.05).The composition ratio of tumor diameter≥5 cm,multiple lesions,vascular invasion,and tumor-free capsule was significantly lower than that of the negative group(P<0.05).The positive rate of Tim-3 expression in patients with recurrence and death within 1 year after surgery was significantly higher than that in patients without recurrence and survival(P<0.05).The expression rate of Galectin-9 was significantly lower in patients with relapse and death than that in patients without recurrence and survival(P<0.05).Conclusion The high expression of Tim-3 and the low expression of Galectin-9 are related to various pathological features of PLC,and there are differences in the expression of Tim-3 and Galectin-9 in patients with recurrence and non-recurrence,and in death and survival patie

关 键 词：T细胞免疫球蛋白粘蛋白-3 半乳糖凝集素-9 原发性肝癌 复发 死亡 

分 类 号：R735.7[医药卫生—肿瘤]