绒毛蛋白及核苷酸还原亚单位M1在不同胃黏膜病变组织中表达研究  

Study of the Expression of Villi and Nucleotide Reduction Subunit M1 in Different Gastric Mucosal Lesions

作　　者：赵帅华[1] Zhao Shuaihua(Department of Pathology,Anyang District Hospital,Puyang 455000)

机构地区：[1]濮阳市安阳地区医院病理科,濮阳455000

出　　处：《数理医药学杂志》2019年第2期161-163,共3页Journal of Mathematical Medicine

摘　　要：目的:观察绒毛蛋白及核苷酸还原亚单位M1(RRM1)在不同胃黏膜病变组织中的表达情况,并对其临床意义进行探讨。方法:选择某院收集的210例胃黏膜活检标本,其中慢性胃炎35例,肠上皮化生36例,低级别上皮内瘤变31例,高级别上皮内瘤变20例,胃癌88例。全部标本予以免疫组织化学方法进行绒毛蛋白及RRM1检测,并对检测结果进行分析。结果:肠上皮化生组、低级别上皮内瘤变组、高级别上皮内瘤变组、胃癌组标本的绒毛蛋白阳性率显著高于慢性胃炎组(P<0.05);低级别上皮内瘤变组、高级别上皮内瘤变组、胃癌组标本的绒毛蛋白阳性率显著低于肠上皮化生组(P<0.05);低级别上皮内瘤变组、高级别上皮内瘤变组、胃癌组标本的RRM1阳性率显著高于慢性胃炎组及肠上皮化生组(P<0.05);慢性胃炎组标本中的RRM1阳性率显著高于肠上皮化生组(P<0.05);绒毛蛋白、RRM1在高中分化胃癌阳性表达显著高于低分化胃癌,差异具有统计学意义(P<0.05)。结论:绒毛蛋白及RRM1的表达与胃癌的发病发展及预后存在一定关系,早期检测能够有效对胃癌进行诊断、病情评估及采取合理的治疗方案,从而改善患者的预后。Objective:To observe the expression of villi and nucleotide reduction subunit M1(RRM1)in different gastric mucosal lesions,and to explore its clinical significance.Methods:210 cases of gastric mucosa biopsy specimens collected in a hospital were selected,35 cases of chronic gastritis,36 cases of intestinal metaplasia,31 cases of low level intraepithelial neoplasia,20 cases of high-grade intraepithelial neoplasia,88 cases of gastric cancer.All the samples were given immunohistochemical method to detect the villi and RRM1,and the test results were analyzed.Results:The positive rate of villi in the patients with intestinal metaplasia group,low-grade epithelial neoplasia group,high grade epithelial neoplasia group and gastric cancer group was significantly higher than that in chronic gastritis group(P<0.05).The positive rate of villi in the low-grade epithelial neoplasia group,the high grade epithelial neoplasia group and the gastric cancer group was significantly lower than that in the intestinal metaplasia group(P<0.05).RRM1 positive rate in low level intraepithelial neoplasia group,high level intraepithelial neoplasia,gastric cancer specimens was significantly higher than that of chronic gastritis and intestinal metaplasia group(P<0.05),positive rate of RRM1 in the chronic gastritis group was significantly higher than that in the intestinal metaplasia group(P<0.05).The positive expression of villi and RRM1 in high and medium level differentiated gastric cancer was significantly higher than that of low level differentiatiated gastric cancer,and the difference was statistically significant(P<0.05).Conclusion:The expression of villi protein and RRM1 is related to the pathogenesis and prognosis of gastric cancer,early detection can effectively diagnose gastric cancer,evaluate illness and take reasonable treatment,so as to improve the prognosis of patients.

关 键 词：绒毛蛋白 核苷酸还原亚单位M1 胃黏膜病变 

分 类 号：R735.2[医药卫生—肿瘤]