上消化道固有肌层肿瘤经内镜黏膜下隧道肿瘤切除术和黏膜下肿瘤挖除术的治疗对比  

Comparative treatment analysis of upper gastroenterology submucosal tumors originating from muscularis propria layer: submucosal tunneling endoscopic resection versus endoscopic submucosal excavation

作　　者：田雪丽[1] 黄永辉[1] 姚炜[1] 李渊[1] 陆京京[1] TIAN Xue-li;HUANG Yong-hui;YAO Wei;LI Yuan;LU Jing-jing(Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China)

机构地区：[1]北京大学第三医院消化科,北京100191

出　　处：《北京大学学报（医学版）》2019年第1期171-176,共6页Journal of Peking University:Health Sciences

基　　金：国家自然科学基金(81470905)~~

摘　　要：目的:评价内镜经黏膜下隧道肿瘤切除术(submucosal tunneling endoscopic resection,STER)和黏膜下肿瘤挖除术(endoscopic submucosal excavation,ESE)治疗上消化道固有肌层肿瘤的疗效和安全性。方法:选择2013年4月至2016年12月在北京大学第三医院诊断为上消化道固有肌层肿瘤并行STER治疗(n=28)和ESE治疗(n=14)的患者病例资料进行回顾分析,分析比较两组的临床病理和内镜结果、治疗和并发症发生情况。结果:42例病变均顺利完成切除,成功率100%。两组间(STER组vs. ESE组)从性别、年龄、病变大小[1. 5(1. 0～6. 0) cm vs.1. 3(0. 5～2. 0) cm,P=0. 056]差异均无统计学意义,STER组的病变切除时间长于ESE组[46. 5 (11. 0～163. 0)min vs. 19. 5(6. 0～56. 0) min,P=0. 007],创面钛夹缝合时间短于ESE组[3. 5(1. 0～11. 0) min vs. 8. 0 (2. 0～33. 0) min,P=0. 006],两组差异均有统计学意义,但总的手术时间的差异无统计学意义[52. 0(14. 0～167. 0) min vs.31. 5(10. 0～88. 0) min,P=0. 080]。术后一次性整块切除率(92. 9%vs. 85. 7%)、治疗后住院时间、术后并发症(10. 7%vs. 0)两组间差异无统计学意义。STER组术后发生肺炎2例,纵隔气肿1例,保守对症支持治疗后痊愈;ESE组术后无并发症发生。术后经常规病理及免疫组化染色确诊平滑肌瘤28例,间质瘤14例。STER组6例间质瘤均为极低危险度; ESE组4例间质瘤为极低危险度,4例间质瘤为中等危险度[病变大小约1. 0～2. 0 cm,核分裂像(6～8)个/50高倍视野]。所有患者中位随访时间46. 5个月(24～60个月),中等危险度间质瘤的患者最短随访时间为32个月,均未见肿瘤残留、复发及隧道内种植。结论:STER和ESE均可成为治疗来源于上消化道固有肌层的黏膜下肿瘤的有效、安全的方案选择之一,与STER相比,ESE切除病变时间短,但创面缝合时间长,总的手术时间相当。Objective:To evaluate the efficacy and safety of submucosal tunneling endoscopic resection (STER) and endoscopic submucosal excavation (ESE) for upper gastroenterology submucosal tumors (SMT) originating from the muscularis propria (MP) layer. Methods: Clinicopathological and endoscopic data of 42 cases with upper gastroenterology tumors originating from the MP layer who were treated with STER (n=28) or ESE (n=14) between April 2013 and December 2016 in Peking University Third Hospital were retrospectively analyzed. The treatment and complications of the two groups were compared. Results: In the study, 42 cases were all resected by therapeutic endoscopy successfully.There was no significant difference (STER vs. ESE) in gender, age, mean tumor size [1.5 (1.0-6.0) cm vs. 1.3 (0.5-2.0) cm,P=0.056]. STER was superior to ESE with reduced sutured time [3.5 (1.0-11.0) min vs. 8.0 (2.0-33.0) min, P=0.006], but more resection time [46.5 (11.0-163.0) min vs.19.5 (6.0-56.0) min, P=0.007]. There was statistical difference between the two groups in resection time or sutured time, but no significant difference (STER vs. ESE) in total operative time [52.0 (14.0-167.0) min vs. 31.5 (10.0-88.0) min, P=0.080]. En bloc resection rates (92.9% vs. 85.7%), hospital stay duration and complications (10.7 vs. 0.0) were similar in the STER and ESE groups. One case developed mediastinal emphysema and 2 pneumonia after operation in STER group, and all of them recovered uneventfully after conservative treatments;There were no complications in the ESE group. After operation, 28 cases of leiomyoma and 14 cases of stromal tumor were diagnosed by routine pathological and immunohistochemical staining. Among them, 6 cases of stromal tumors in group STER were all extremely low risk, 4 cases of stromal tumors in group ESE were extremely low risk, 4 cases of stromal tumors in group ESE were medium risk (the size of the lesion was about 1.0-2.0 cm, and mitotic figures counted (6-8)/50 high power field). The median follow-up time of all the patients wa

关 键 词：上消化道固有肌层肿瘤 内镜 对比研究 内镜经黏膜下隧道肿瘤切除术 内镜黏膜下肿瘤挖除术 

分 类 号：R735[医药卫生—肿瘤]