Tegafur deteriorates established cardiovascular atherosclerosis in colon cancer: A case report and review of the literature  

作　　者：Shi-Chang Zhang Meng-Yao Yu Lei Xi Jie-Xin Zhang 

机构地区：[1]Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University [2]Department of Pathology, the First Affiliated Hospital of Nanjing Medical University

出　　处：《World Journal of Clinical Cases》2019年第1期89-94,共6页世界临床病例杂志

基　　金：Supported by National Natural Science Foundation of China,No.81501817 and No.81671836;Natural Science Youth Foundation of Jiangsu Province,No.BK20151029;the Key Laboratory for Laboratory Medicine of Jiangsu Province of China,No.ZDXKB2016005

摘　　要：BACKGROUND Cardiac toxic effect of tegafur(S-1) is extremely rare, and there has been no report on this issue so far.CASE SUMMARY We herein report a typical case of single S-1 administration after radical operation for colon cancer. The patient had no background or medical history of acute coronary syndrome(ACS), and only aortic and coronary atherosclerosis was revealed by computed tomography(CT) before surgery. He complained of sternum pain during the fifth cycle of S-1 treatment. Electrocardiogram(ECG)and serum cardiac marker cardiac troponin T(cTnT) strongly suggested ACS,which was possibly caused by S-1 cardiotoxicity.CONCLUSION Monitoring protocols based on ECG, CT, and cTnT should be performed in real time to evaluate cardiac function during S-1 administration.BACKGROUND Cardiac toxic effect of tegafur(S-1) is extremely rare, and there has been no report on this issue so far.CASE SUMMARY We herein report a typical case of single S-1 administration after radical operation for colon cancer. The patient had no background or medical history of acute coronary syndrome(ACS), and only aortic and coronary atherosclerosis was revealed by computed tomography(CT) before surgery. He complained of sternum pain during the fifth cycle of S-1 treatment. Electrocardiogram(ECG)and serum cardiac marker cardiac troponin T(cTnT) strongly suggested ACS,which was possibly caused by S-1 cardiotoxicity.CONCLUSION Monitoring protocols based on ECG, CT, and cTnT should be performed in real time to evaluate cardiac function during S-1 administration.

关 键 词：S-1 Acute CORONARY syndrome COMPUTED tomography ELECTROCARDIOGRAM Cardiac TROPONIN T Case report 

分 类 号：R[医药卫生]