缺血性脑白质病变患者发生认知功能障碍的影响因素分析  

Pathogenesy Influencing Factors of Cognitive Dysfunction in Patients with Ischemic Leukodystrophy

作　　者：夏瑞雪[1] 李艳华[1] 张丽冉[1] 戴建宁[1] 王菁[2] XIA Rui-xue;LI Yan-hua;ZHANG Li-ran;DAI Jian-ning;WANG Jing(The Second Department of Neurology, Central Hospital of Cangzhou, Cangzhou, Hebei 061000, China;Department of Neurology, the First Hospital of Shijiazhuang, Shijiazhuang 050000, China)

机构地区：[1]沧州市中心医院神经内二科,河北沧州061000 [2]石家庄市第一医院神经内科,石家庄050000

出　　处：《解放军医药杂志》2019年第3期108-111,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：河北省医学科学研究重点课题(20181006);沧州市重点研发计划指导项目(172302135)

摘　　要：目的探讨缺血性脑白质病变患者发生认知功能障碍的影响因素。方法选择2015年1月—2017年12月收治的缺血性脑白质病变患者226例作为观察组,选择同期体检未发生脑白质病变者116例作为对照组。比较2组的认知功能障碍发生率和蒙特利尔认知评估量表(MoCA)评分。分析缺血性脑白质病变患者发生认知功能障碍的独立危险因素。结果观察组认知功能障碍发生率高于对照组(P<0.05)。观察组视空间能力、注意力、抽象力、延迟回忆以及MoCA总分均明显低于对照组(P<0.05)。年龄>65岁和高血压是缺血性脑白质病患者变发生认知功能障碍的独立危险因素(P<0.05)。结论缺血性脑白质病变患者认知功能障碍发生率高,临床应积极控制血压,避免发生认知功能障碍。Objective To investigate influencing factors of cognitive dysfunction in patients with ischemic leukodystrophy. Methods A total of 226 patients with ischemic leukoencephalopathy admitted during January 2015 and December 2017 were selected as observation group, while 116 patients without leukoencephalopathy at the same period were selected as control group. In two groups, incidence rate of cognitive dysfunction and Montreal cognitive assessment scale (MoCA) scores were compared, and independent risk factors of cognitive dysfunction in patients with ischemic leukodystrophy were analyzed. Results In observation group, incidence rate of cognitive dysfunction was significantly higher ( P <0.05), while values of visual spatial ability, attention, abstraction, delayed memory and total MoCA score were significantly lower than those in control group ( P <0.05). More than 65 years old and hypertension were independent risk factors for pathogenesy of cognitive dysfunction in patients with ischemic leukodystrophy ( P <0.05). Conclusion Incidence rate of cognitive dysfunction in patients with ischemic leukodystrophy is high, and therefore blood pressure should be controlled actively to avoid pathogenesy of cognitive dysfunction.

关 键 词：脑白质病 认知障碍 危险因素 

分 类 号：R749.13[医药卫生—神经病学与精神病学]