基于海马纹理特征的阿尔茨海默病早期识别  

Early classification of Alzheimer's Disease based on hippocampal texture features

作　　者：赵坤 丁艳辉[1] 张增强[2] 周波[2] 姚洪祥[3] 王盼[2] 冯枫[2] 郑元杰[1] 刘勇[4] 张熙[2] ZHAO Kun;DING Yanhui;ZHANG Zengqiang;ZHOU Bo;YAO Hongxiang;WANG Pan;FENG Feng;ZHENG Yuanjie;LIU Yong;ZHANG Xi(School of Information Science and Engineering,Shandong Normal University,Jinan Shandong 250014,China;Department of Internal Neurology,Chinese PLA General Hospital,Beijing 100853,China;Radiology Department,Chinese PLA General Hospital,Beijing 100853,China;Institute of Automation,Chinese Academy of Sciences,Beijing 100190,China)

机构地区：[1]山东师范大学信息科学与工程学院,山东济南250014 [2]解放军总医院南楼神经内科,北京100853 [3]解放军总医院南楼放射科,北京100853 [4]中国科学院自动化研究所,北京100190

出　　处：《太赫兹科学与电子信息学报》2019年第1期136-140,共5页Journal of Terahertz Science and Electronic Information Technology

基　　金：国家自然科学基金资助项目(81471120);山东省重点研发计划资助项目(2017GGX10112);山东省高等学校科技计划资助项目(J15LN24)

摘　　要：阿尔茨海默病(AD)是一种神经退行性疾病。随着脑医学影像的发展,对AD诊断的精确度也在进一步提高,但对AD的诊断,客观上仍缺少好的生物标记。为寻找到AD的更稳定的生物标记,利用海马的影像组学特征对海马的信号强度、形状、灰度阶梯分布等特征进行刻画,通过方差分析(ANOVA)和事后检验,在统计学上寻找出正常对照(NC)、AD、轻度认知损害(MCI)之间存在差异的特征;通过与被试的简易智能状况检查(MMSE)评分进行相关性分析,找寻与MMSE评分相关性较高的特征;利用支持向量机(SVM)构建一个对AD和NC分类的模型,交叉验证得到的正确率为86%。结果表明,海马的影像组学特征是一个很好的生物标记,能对AD进行有效的早期识别。Alzheimer's Disease(AD)is a neurodegenerative disease.With the development of brain imaging,the accuracy of AD diagnosis has been well improved.However,there still lack of good markers to early diagnosis of AD.In order to find more stable biomarkers of AD,the hippocampus intensity,shape,grayscale gradient distribution and other characteristics are investigated by an Analysis Of Variance and post-hoc analysis so as to identify the alteration in AD and Mild Cognitive Impairment(MCI)in comparison to Normal Controls(NC).The results show that the Mini-Mental State Examination(MMSE)scores are significantly associated with the radiomic features of the bilateral hippocampus.The classification analysis with the Support Vector Machine(SVM)shows that an accuracy of 86%can be obtained with leaving one out cross validation,which indicates that the hippocampal texture might be taken as one of the potential markers for AD.

关 键 词：阿尔茨海默病 海马 影像组学特征 支持向量机 

分 类 号：TN911.7[电子电信—通信与信息系统] R455[电子电信—信息与通信工程]