中枢神经系统耐甲氧西林金黄色葡萄球菌感染治疗方案选择  

Selection of treatment options for methicillin-resistant staphylococcus aureus infection in the central nervous system

作　　者：贾亮亮[1] 汪震 邢翔飞[1] 彭官良[1] 金桂兰[1] 奚炜[1] JIA Liangliang;WANG Zhen;XING Xiangfei;PENG Guanliang;JIN Guilan;XI Wei(Department of Pharmacy,The People s Hospital of China Three Gorges University,First People's Hospital of Yichang,Yichang,Hubei 443000,China;Department of Pharmacy,Tongji Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan,Hubei 430030,China)

机构地区：[1]三峡大学人民医院宜昌市第一人民医院药学部,湖北宜昌443000 [2]华中科技大学同济医学院附属同济医院药学部,湖北武汉430030

出　　处：《安徽医药》2019年第4期831-834,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：万古霉素、替考拉宁、利奈唑胺是临床常用的治疗耐甲氧西林金黄色葡萄球菌(MRSA)感染的抗菌药物,由于其不同的药代动力学及不良反应特点导致其在临床应用中的侧重点各有不同。由于血脑屏障的存在,中枢神经系统感染尤其是MRSA感染的治疗尤为困难。该研究从药代动力学方面分析了替考拉宁在中枢神经系统感染中的应用以及从药物疗效、药物经济学及药物不良反应三个方面比较了万古霉素脑室给药和利奈唑胺外周静脉给药对于中枢神经系统MRSA感染的优劣,为临床颅内感染治疗方案的选择提供借鉴意义。Vancomycin,Teicoplanin and Linezolid are commonly used antibacterial drugs for the treatment of methicillin-resistant staphylococcus aureus(MRSA)infection.Because of the different characteristics of pharmacokinetics and adverse reaction,the clinical application ranges are not the same between Vancomycin,Teicoplanin and Linezolid.Due to the presence of the blood-brain barrier,the treatment of central nervous system infections,especially MRSA infection,is particularly difficult.In this paper,the application of Teicoplanin in central nervous system infection was analyzed from the point of pharmacokinetics characteristics,and the advantages and disadvantages of intracerebroventricular administration of Vancomycin and peripheral intravenous administration of Linezolid for the central nervous system MRSA infection were compared from the point of drug efficacy,pharmacoeconomics and adverse drug reactions with the purpose to provide reference for the selection of treatment options for central nervous system infection.

关 键 词：中枢神经系统细菌感染 注射 脑室内 注射 静脉内 治疗结果 药代动力学 万古霉素 替考拉宁 利奈唑胺 

分 类 号：R742.9[医药卫生—神经病学与精神病学]