幽门螺杆菌对抗菌药物耐药的研究进展  

Advances in Study on Antibiotic Resistance of Helicobacter pylori

作　　者：陈梅红[1] 严谨[1] 党旖旎[1] 张国新[1] CHEN Meihong;YAN Jin;DANG Yini;ZHANG Guoxin(Department of Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029)

机构地区：[1]南京医科大学第一附属医院消化内科,210029

出　　处：《胃肠病学》2019年第2期115-118,共4页Chinese Journal of Gastroenterology

摘　　要：目前已证实幽门螺杆菌(Hp)与多种消化道和消化道外疾病有关。近年来,既往经典三联治疗方案的成功根除率逐渐降低,最主要的原因是抗菌药物耐药以及治疗方案的不规范实施。根除治疗方案的选择应基于当地抗菌药物耐药情况,必要时进行个体敏感性测试。同时,对耐药机制的深入研究有利于降低根除失败率,减少耐药发生。本文就Hp对抗菌药物耐药的研究进展作一综述。Helicobacter pylori (Hp) has been confirmed to be associated with a variety of gastrointestinal tract and extra-gastrointestinal diseases. The eradication rate of classic triple therapy regimen was reduced gradually in recent years, and it was shown that antibiotic resistance and irregular treatment were the main causes of the failure of eradication. The choice of treatment should be based on the local antibiotic resistance situation, if necessary, individual sensitivity tests should be considered. At the same time, the in-depth study on mechanisms of drug resistance is helpful to decrease the eradication failure and reduce the drug resistance. This article reviewed the advances in study on antibiotic resistance of Hp.

关 键 词：幽门螺杆菌 根除治疗 抗菌药物耐药 

分 类 号：R57[医药卫生—消化系统]