hrHPV E6/E7 mRNA检验在宫颈癌筛查中的意义  

Significance of hrHPV E6/E7 mRNA Test in Cervical Cancer Screening

作　　者：隋娟 SUI Juan(Shangqiu First People’s Hospital Shangqiu, Shangqiu, Henan, 476100, China)

机构地区：[1]商丘市第一人民医院,河南商丘476100

出　　处：《临床研究》2019年第3期139-140,共2页Clinical Research

摘　　要：目的探究高危型人乳头病毒(hrHPV)E6/E7 mRNA检验在宫颈癌筛查中的临床意义。方法以2014年4月～2018年3月之间的371例宫颈癌筛查患者作为研究对象,所有患者均液基细胞学(TCT)、阴道镜活检、hrHPVE6/E7 mRNA检验,以阴道镜下病理活检结果为金标准,对比分析不同病理级别患者的hrHPV E6/E7 mRNA检验阳性率,并对比TCT和hrHPV E6/E7 mRNA检验的阳性率、敏感性、特异性。结果病理检验结果显示,371例患者中炎症191例,宫颈上皮内瘤变(CIN)Ⅰ 121例,CIN Ⅱ～Ⅲ 55例,宫颈癌4例,hrHPV E6/E7 mRNA检验结果阳性率分别为60.7%、68.6%、89.1%、100.0%;hrHPV E6/E7 mRNA检验的阳性率、敏感性均显著高于TCT检验,但特异性明显低于TCT检验(P <0.05)。结论 hrHPV E6/E7 mRNA检验用于宫颈癌筛查具有一定的临床价值,具有较高的阳性率及敏感性,但特异性相对较低,建议与其他检验方案联合应用。Objective To investigate the clinical significance of high-risk human papillomavirus (hrHPV) E6/E7 mRNA test in cervical cancer screening. Methods A total of 371 cervical cancer screening patients between April 2014 and March 2018 were enrolled. All patients underwent liquid-based cytology (TCT), colposcopy biopsy, and hrHPV E6/E7 mRNA test to the vagina. The results of microscopic pathological biopsy were gold standard. The positive rate of hrHPV E6/E7 mRNA in patients with different pathological grades was compared and compared with the positive rate, sensitivity and specificity of TCT and hrHPV E6/E7 mRNA test. Results The results of pathological examination showed that 191 cases of inflammation in 371 cases, 121 cases of cervical intraepithelial neoplasia (CIN) I, 55 cases of CIN II ~??, 4 cases of cervical cancer, the positive rate of hrHPV E6/E7 mRNA test results were 60.7%, 68.6%, 89.1%, 100.0%;the positive rate and sensitivity of hrHPV E6/E7 mRNA test were significantly higher than TCT test, but the specificity was significantly lower than TCT test, the difference was statistically significant (P < 0.05). Conclusion hrHPV E6/E7 mRNA test has certain clinical value for cervical cancer screening, with high positive rate and sensitivity, but the specificity is relatively low. It is recommended to be combined with other test protocols.

关 键 词：高危型人乳头病毒 MRNA 宫颈癌 检验 

分 类 号：R737.33[医药卫生—肿瘤]