新型锌配合物的合成、表征与生物活性的研究  

Synthesis,Characterization and Bioactivity of the New Zinc (Ⅱ) Complexes

作　　者：陈程云 康杰[1] 孙伟明[1] 翁清花 黄胜[1] CHEN Cheng-yun;KANG Jie;SUN Wei-ming;WENG Qing-hua;HUANG Sheng(College of pharmacy,Fujian Medical University,Fuzhou 350108,China)

机构地区：[1]福建医科大学药学院,福州350108

出　　处：《海峡药学》2019年第2期54-57,共4页Strait Pharmaceutical Journal

基　　金：福建省自然科学基金资助项目(2015J01597;2016J05032);福建医科大学教授基金(JS14008)

摘　　要：目的合成新型芳香羧酸三氮唑锌配合物Zn(C_(10)H_5N_3O_5)·H_2O(配合物1)、Zn_2(C_(10)H_5N_3O_(4.5))_2·H_2O(配合物2),并研究其生物活性。方法采用水热法合成,借用紫外可见光谱、荧光光谱、红外光谱、旋光度和X射线单晶衍射对单晶产物进行表征。通过密度泛函理论(DFT)计算配合物的NBO电荷和HOMO轨道。结果与结论运用MTT法,两种配合物呈现一定的细胞毒性与选择性抑制作用。OBJECTIVE ome new aromatic carboxylic triazole zinc(Ⅱ)complexes including Zn(C 10 H 5N 3O 5)·H 2O(complex 1)and Zn 2(C 10 H 5N 3O 4.5)2·H 2O(complex 2)and study its bioactivity.METHODS They was synthesized by hydrothermal synthesis and characterized by IR,UV-Vis,emission spectra and optical activity.The crystal structure of this complex was determined based on single-crystal X-ray diffraction data.By means of density functional theory(DFT)computation,the natural bond orbital(NBO)charges and frontier orbital of this complex were also analyzed.RESULTS AND CONCLUSION Using the determined by MTT method,the studied complexes show moderate cytotoxicity and selective inhibition effect.

关 键 词：芳香羧酸三氮唑 锌配合物 量子化学 抗癌活性 

分 类 号：R917[医药卫生—药物分析学]