睫状神经营养因子与老年脑卒中后抑郁的相关性研究  

Relationship between ciliary neurotrophic factor and post-stroke depression in the elderly

作　　者：谭贤佩 夏烈新[1] 李知莲[1] 马兰[1] TAN Xianpei;XIA Liexin;LI Zhilian(Department of Neurology,The First People’s Hospital of Jingzhou City,Hubei,Jingzhou 434000,China)

机构地区：[1]湖北省荆州市第一人民医院神经内科,434000

出　　处：《河北医药》2019年第5期710-713,共4页Hebei Medical Journal

摘　　要：目的探讨睫状神经营养因子(CNIF)与老年脑卒中后抑郁的相关性。方法选择2015年7月至2017年12月诊治的脑卒中后抑郁患者46例为观察组,健康老年人46例为对照组。检测2组血清CNTF浓度并比较其差异。同时对2组患者进行HAMD、NIHSS、ADL评分评估。结果观察组患者HAMD、NIHSS、ADL评分均显著高于对照组(P<0.05),但其CNTF明显低于对照组(P<0.05),差异有统计学意义(P<0.05)。观察组卒中部位及前后循环的影响下CNTF差异无统计学意义(P>0.05),但在病灶体积、HAMD评分和NIHSS评分中差异有统计学意义(P<0.05)。观察组CNTF与病灶体积、HAMD评分和NIHSS呈负相关(rs<0,P<0.05)。Logistic回归分析显示,病灶体积,CNTF浓度引起患者死亡或严重的并发症的OR值分别为1.87和1.45。结论睫状神经因子过低可能会导致老年卒中后抑郁的发生,且为独立的危险因素。Objective To investigate the relationship between ciliary neurotrophic factor(CNTF)and post-stroke depression in the elderly.Methods Forty-six patients with post-stroke depression who were treated in our hospital from July 2015 to December 2017 were enrolled as observation group,and 46 healthy elderly patients were enrolled as control group.The serum CNTF concentrations were detected and compared between the two groups.Moreover the HAMD,NIHSS,and ADL scores were evaluated and compared between the two groups.Results The scores of HAMD,NIHSS and ADL in observation group were significantly higher than those in control group(P<0.05),but the levels of CNTF were significantly lower than those in control group(P<0.05).There were no significant differences in CNTF levels in stroke position and after the influence of anterior-posterior circulation in observation group(P>0.05),but there were significant differences in lesion volume,HAMD scores and NIHSS scores(P<0.05).Moreover the CNTF levels in observation group were negatively correlated with lesion volume,HAMD scores and NIHSS(rs<0,P<0.05).Logistic regression analysis showed that the OR value of lesion volume and CNTF levels that caused death or serious complications in patients was 1.87 and 1.45,respectively.Conclusion The low levels of CNTF may result in post-stroke depression in elderly patients,which is an independent risk factor.

关 键 词：老年脑卒中 抑郁 睫状神经营养因子 

分 类 号：R749.42[医药卫生—神经病学与精神病学]