LncRNAs在细胞衰老中的作用和治疗靶标  

Role of LncRNAs in cell senescence and therapeutic targets

作　　者：戴凯琴 刘俊 凌霜 许锦文 DAI Kai-qin;LIU Jun;LING Shuang;XU Jin-wen(Murad Research Institute for Modernized Chinese Medicine,Institute of Interdisciplinary Medical Science,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学交叉科学研究院穆拉德中药现代研究中心,上海201203

出　　处：《中国药理学通报》2019年第4期464-467,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81274130);上海市教委085项目高等教育内涵建设基金(No 085ZY1202)

摘　　要：长链非编码RNA(long non-coding RNAs,LncRNAs)是一类转录本长度超过200 bp的非编码RNA。细胞衰老是一种稳定的增殖性停滞状态,这种不可逆的细胞停滞状态可能由多种因素引起,如端粒缩短、癌基因诱导或氧化应激。多因素参与细胞衰老,但p53/p21和p16/Rb是不同细胞类型中细胞衰老的主要调节途径。细胞衰老作为一种强大的肿瘤抑制机制已经被广泛研究,以抵抗致癌基因的出现。该文将深入探讨LncRNAs在细胞衰老中的作用机制和治疗靶标。Long non-coding RNAs(LncRNAs) are non-coding RNAs with a length of more than 200 bp.Cellular senescence is a stable proliferative stagnation state,which is irreversible and may be caused by a variety of factors,such as telomere shortening,oncogene induction or oxidative stress.Multiple factors are involved in cellular senescence,in which p53/p21 and p16/Rb are major regulators of cellular senescence in different cell types.Cellular aging has been extensively studied as a powerful tumor suppressor mechanism to counter the emergence of oncogenes.In this review,the mechanism of action and therapeutic targets of LncRNAs in senescent cells are explored in depth.

关 键 词：长链非编码RNA 细胞衰老 P53 P16 衰老相关性疾病 治疗靶标 

分 类 号：R-05[医药卫生] R339.38