局部晚期宫颈癌患者化疗前后血清VEGF、CEA和SCC-Ag水平变化及其与化疗敏感性的相关性分析  

Changes in Serum Levels of VEGF,CEA and SCC-Ag in Patients with Locally Advanced Cervical Cancer Before and After Chemotherapy and Their Correlations with Chemosensitivity

作　　者：董格[1] 张文先[1] 罗琼[1] 杨华清[2] DONG Ge;ZHANG Wen-xian;LUO Qiong;YANG Hua-qing(Department of Obstetrics and Gynecology,Guangyuan Central Hospital,Guangyuan 628000,China;Department of Oncology,Guangyuan Central Hospital,Guangyuan 628000,China)

机构地区：[1]广元市中心医院妇产科,四川广元628000 [2]广元市中心医院肿瘤科,四川广元628000

出　　处：《标记免疫分析与临床》2019年第3期407-411,共5页Labeled Immunoassays and Clinical Medicine

摘　　要：目的分析局部晚期宫颈癌患者化疗前后血清血管内皮生长因子(VEGF)、癌胚抗原(CEA)和鳞状细胞癌相关抗原(SCC-Ag)水平变化及其与化疗敏感性的相关性。方法选取2013年1月至2018年1月我院收治的局部晚期宫颈癌患者250例为研究对象,均接受紫杉醇联合顺铂(TP)新辅助化疗,分析其化疗前、化疗1个周期、化疗2个周期后血清VEGF、CEA和SCC-Ag水平,并依据RECIST1.1版肿瘤疗效评价标准将其分为化疗敏感组(n=178)、化疗不敏感组(n=72),对比两组化疗前后血清VEGF、CEA和SCC-Ag水平,按照化疗后VEGF、CEA和SCC-Ag下降百分比将其分为<40%组、40%～70%组、>70%组,对比其肿瘤直径变化值与化疗反应率,分析血清VEGF、CEA和SCC-Ag下降百分比与化疗敏感性的相关性。结果化疗1个周期、化疗2个周期后患者血清VEGF、CEA和SCC-Ag水平均下降(P<0.05);化疗敏感组化疗前血清VEGF、CEA和SCC-Ag水平高于不敏感组,而化疗后血清VEGF、CEA和SCC-Ag水平低于化疗不敏感组(P<0.05); VEGF、CEA和SCC-Ag水平下降<40%组、40%～70%组、> 70%组所对应的肿瘤直径变化值与化疗反应率比较差异均有统计学意义(P <0. 05) Spearman相关性分析发现,局部晚期宫颈癌患者化疗后VEGF、CEA和SCC-Ag下降百分比与化疗敏感性呈正相关(P<0.05)。结论局部晚期宫颈癌患者化疗前后VEGF、CEA和SCC-Ag水平变化与其化疗敏感性呈正相关,VEGF、CEA和SCC-Ag水平下降幅度越大其化疗敏感性越高,肿瘤直径减少、化疗反应率越高。Objective To analyze the changes in serum levels of vascular endothelial growth factor(VEGF),carcinoembryonic antigen(CEA)and squamous cell carcinoma-associated antigen(SCC-Ag)in patients with locally advanced cervical cancer before and after chemotherapy and their correlations with chemosensitivity.Methods A total of 250 patients with locally advanced cervical cancer treated in the hospital from January 2013 to January 2018 were selected for the study.All of them were treated by neoadjuvant chemotherapy with paclitaxel and cisplatin(TP).The levels of serum VEGF,CEA and SCC-Ag were analyzed before chemotherapy,as well as after 1 cycle and 2 cycles of chemotherapy.The patients were divided into the chemotherapy-sensitive group(n=178)and the chemotherapy-insensitive group(n=72)according to the RECIST1.1 edition of response evaluation criteria in tumors.The levels of serum VEGF,CEA and SCC-Ag were compared between the two groups before and after chemotherapy.The patients were further divided into<40%group,40%-70%group and>70%group according to the decreasing percentages of VEGF,CEA and SCC-Ag after chemotherapy.The changes of tumor diameter and chemotherapy response rate were compared between groups.The correlations of the decreasing percentages of serum VEGF,CEA and SCC-Ag with chemosensitivity were analyzed.Results The levels of serum VEGF,CEA and SCC-Ag were decreased after 1 cycle and 2 cycles of chemotherapy(P<0.05).The levels of these markers were significantly higher in the chemotherapy-sensitive group than in the chemotherapy-insensitive group before chemotherapy,while lower after chemotherapy(P<0.05).There were significant differences in the change value of tumor diameter and chemotherapy response rate among the<40%group,40%-70%group and>70%group(P<0.05).Spearman correlation analysis found that the decreasing percentages of VEGF,CEA and SCC-Ag in patients with locally advanced cervical cancer after chemotherapy were positively correlated with chemosensitivity(P<0.05).Conclusion The changes in serum levels o

关 键 词：局部晚期 宫颈癌 VEGF CEA SCC-AG 化疗敏感性 相关性 

分 类 号：R737.33[医药卫生—肿瘤]