Gankyrin在炎症相关性癌症中的作用机制研究进展  

Progress in the mechanism of Gankyrin in inflammation-associated cancers

作　　者：金洋 郑桐森 张艳桥 Jin Yang;Zheng Tongsen;Zhang Yanqiao(Department of Oncology,the Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150000,China;Department of Oncology,the Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150000,China)

机构地区：[1]哈尔滨医科大学研究生学院肿瘤学系,黑龙江哈尔滨150000 [2]哈尔滨医科大学研究生学院肿瘤内科,黑龙江哈尔滨150000

出　　处：《现代肿瘤医学》2019年第7期1247-1251,共5页Journal of Modern Oncology

摘　　要：慢性非可控性炎症是癌症发生发展的基本微环境。约1/4癌症病例的病因和发病机制与感染和慢性炎症相关。Gankyrin是一个重要的癌蛋白,它在多种恶性肿瘤中高表达,并在癌症发生发展中起着关键的作用。近期研究发现Gankyrin在结肠炎相关性结肠癌(colitis-associated cancer,CAC)和慢性肝炎向肝细胞肝癌(hepatocellular carcinoma,HCC)发展的过程中扮演着重要的角色。同时,Gankyrin与多种细胞因子以及炎症信号通路密切相关。本文对Gankyrin在炎症相关性癌症中的作用机制研究进展作一简要综述。Chronic uncontrollable inflammation is the basic microenvironment of cancer development.Infection and chronic inflammation contribute to about 1 in 4 of all cancer cases.Gankyrin is a crucial oncoprotein that is overexpressed in many malignancies and plays a pivotal role in the initiation and progression of cancer.Recent studies have shown that Gankyrin plays an important role in colitis-associated cancer(CAC) and the development of chronic hepatitis to hepatocellular carcinoma(HCC).Meanwhile,Gankyrin is closely related to a variety of cytokines and inflammatory signaling pathways.This review briefly summarized the progess in the mechanism of gankyrin in inflammation-associated cancers.

关 键 词：Gankyrin 炎症相关性癌症 细胞因子 炎症信号通路 

分 类 号：R730.231[医药卫生—肿瘤]