经皮椎体成形术联合放疗治疗椎体转移癌的疼痛及生活质量分析  

Bodily pain and quality of life evaluation on percutaneous vertebroplasty combined with radiotherapy for vertebral metastases

作　　者：姚维 郭良玉 李丙男 谢佳 YAO Wei;GUO Liangyu;LI Bingnan;XIE Jia(Orthopedic Surgery,Chaoyang Central Hospital,Chaoyang 122000,Liaoning,China;Pathology Department,Chaoyang Central Hospital,Chaoyang 122000,Liaoning,China)

机构地区：[1]朝阳市中心医院骨外科,辽宁朝阳1220000 [2]朝阳市中心医院病理科,辽宁朝阳1220000

出　　处：《癌症进展》2019年第5期599-602,共4页Oncology Progress

摘　　要：目的探讨经皮椎体成形术(PVP)联合放疗对椎体转移癌患者疼痛、体力状态及生活质量的影响。方法回顾性分析75例椎体转移癌患者的临床资料。根据治疗方法不同,分为观察组(PVP联合放疗)38例与对照组(单纯放疗)37例。采用视觉模拟评分法(VAS)评估并比较两组患者治疗前、治疗后24 h、治疗后7天、治疗后1个月及治疗后3个月的疼痛情况,采用美国东部肿瘤协作组(ECOG)体力状态评分表及日常生活活动能力(ADL)量表评估并比较两组患者治疗前及治疗后3个月的体力状态及生活质量。结果两组患者的VAS评分比较,差异有统计学意义(P﹤0.05);观察组与对照组不同时间点的VAS评分比较,差异均有统计学意义(P﹤0.05);两组患者VAS评分在时间和组间之间存在交互作用(P﹤0.01)。两组患者治疗前ECOG体力状态评分分布比较,差异无统计学意义(P﹥0.05);治疗后3个月,两组患者ECOG体力状态评分分布比较,差异有统计学意义(P﹤0.05)。治疗后3个月,观察组患者ECOG体力状态评分为0级及1级的总比例为78.95%(30/38),高于对照组的56.76%(21/37)。两组患者治疗前ADL评分比较,差异无统计学意义(P﹥0.05);治疗后3个月,观察组患者的ADL评分明显高于对照组(P﹤0.01)。结论与单纯放疗相比,椎体转移癌患者接受PVP联合放疗,可减轻疼痛,改善体力状态,提高生活质量。Objective To investigate the effect of percutaneous vertebroplasty(PVP)combined with radiotherapy on vertebral metastasis patients in terms of bodily pain,performance status and quality of life.Method The retrospective analysis was conducted on the clinical data from 75 vertebral metastasis patients,out of which 38 patients treated with PVP combined with radiotherapy were assigned into the observation group,and 37 with only radiotherapy into the control group.The before treatment and 24-hour,7-day,1-month,3-month after treatment bodily pain condition was evaluated with the visual analogue scale(VAS),while the performance status rating scale of Eastern Cooperative Oncology Group(ECOG)and the activities of daily life(ADL)measurement were adopted to assess and compare before treatment and 3-month after treatment performance status and quality of life.Result With regard to VAS scores at different time points for patients in the observation group and the control group,intergroup and intragroup differences were all statistically significant(P<0.05);There was an interaction between time and inter-group comparison in VAS scores of patients in both groups(P<0.01).When comparing the ECOG performance status rating distribution between two groups,no significant difference was indicated before surgery(P>0.05),but the difference was found significant based on the data at 3-month after treatment(P<0.05).At 3 months after treatment,the proportion of patients with ECOG performance status 0 or 1 was 78.95%(30/38)in the observation group,higher than that of control group,56.76%(21/37).Further,there was no significant difference in preoperative ADL scores between the two groups(P>0.05).The ADL score of the patients in the observation group was significantly higher than that of the control group at 3 months after treatment(P<0.01).Conclusion Compared with radiotherapy alone,PVP combined with radiotherapy is able to relieve the bodily pain for vertebral metastases patients,to improve their performance status and quality of life.

关 键 词：经皮椎体成形术 椎体转移癌 放疗 治疗效果 

分 类 号：R738.1[医药卫生—肿瘤]