Sirtuins家族蛋白及其在糖脂代谢中的作用  

Sirtuins Family Proteins and Its Role in Regulating Glycolipid Metabolism

作　　者：韦晓[1] 汪奇峰 陈煜[1] 杨雪[1] 陈国芳[1] 刘超[1] WEI Xiao;WANG Qifeng;CHEN Yu;YANG Xue;CHEN Guofang;LIU Chao(Department of Endocrinology,Affiliated Hospital of Integrated Traditional Chinese and Western Medicine of Nanjing University of Chinese Medicine/Jiangsu Province Academy of Traditional Chinese Medicine,Nanjing 210028,China)

机构地区：[1]南京中医药大学附属中西医结合医院内分泌科江苏省中医药研究院瘿病证治重点研究室,南京210028

出　　处：《医学综述》2019年第5期845-849,共5页Medical Recapitulate

基　　金：国家自然科学基金(81800756;81600600)

摘　　要：热量限制可有效改善糖脂代谢紊乱,此过程被激活的Sirtuins家族蛋白是影响糖脂代谢的重要分子。Sirtuins家族蛋白是一种烟酰胺腺嘌呤二核苷酸依赖的去乙酰化酶,普遍存在于各种细胞中,广泛参与了糖类和脂类的代谢,通过影响AMP活化的蛋白激酶、过氧化物酶体增殖物激活受体γ共激活因子1α、叉头蛋白转录因子O1等蛋白的表达和活性影响糖脂类代谢,维持体内的代谢平衡。因此,通过增加Sirtuins家族蛋白的表达,可以改善糖脂代谢紊乱,降低患衰老性疾病的风险。Caloric restriction can effectively improve glucolipid metabolic disorder,and sirtuins family proteins activated in this process are important molecules affecting the glycolipid metabolism.Sirtuins are NAD-dependent deacetylases,widespread in a variety of cells,and widely involved in the metabolisms of carbohydrates and lipids.Sirtuins regulate glycolipid metabolism to maintain the metabolic balance by affecting the expression and activity of AMP-activated protein kinase,peroxisome proliferator activated receptor γ coactivator 1α,and forkhead box protein O1.Therefore,increasing the expression of sirtuins can improve the glyeolipid metabolism disorder and reduce the risk of aging diseases.

关 键 词：SIRTUINS 糖代谢 脂代谢 糖脂代谢紊乱 

分 类 号：R589[医药卫生—内分泌]