125I放射性粒子植入联合微波消融治疗胸部巨大胸腺瘤(>7cm)的疗效评估分析  

作　　者：冯潇 汤登尧 杨海涛[1] 童向东 王振元[1] 

机构地区：[1]辽宁省人民医院胸外科,辽宁沈阳110016

出　　处：《医药界》2018年第23期159-160,共2页

基　　金：辽宁省科学计划项目,编号20170540520.

摘　　要：目的探讨125I放射性粒子植入联合微波消融(microwave ablation,MWA)治疗胸部巨大胸腺瘤患者(>7㎝)的近期疗效及评估分析。方法回顾性分析18例经125I放射性粒子植入联合微波消融治疗的胸部巨大胸腺瘤患者(>7㎝)的近期临床疗效、生存时间和生活质量、疼痛缓解程度及治疗后的并发症与不良反应。结果125I放射性粒子植入联合微波消融治疗胸部巨大胸腺瘤患者(>7㎝)的总有效率14/18(77.8%),术后3个月生存率15/18(83.3%),术后6个月生存率13/18(72.2%),术后9个月生存率12/18(66.7%),术后12个月生存率11/18(61.1%)。结论单纯125I放射性粒子植入治疗胸部巨大胸腺瘤患者(>7㎝)辐射剂量大,需多次植入,放射性损伤大,125I放射性粒子植入同时联合微波消融治疗,辐射剂量小,并发症少,近期疗效好,疼痛缓解明显,成为胸部巨大胸腺瘤患者(>7㎝)治疗的一种新选择。Purpose:To investigate the short-term efficacy of 125I radioactive seed implantation combined with microwave ablation(MWA)in the treatment of giant thymoma of chest(>7cm).Methods:A retrospective analysis was made on the clinical efficacy,survival time,survival quality,easement of pain,complications and adverse reactions of 18 patients with giant thymoma of chest(>7cm)treated by 125I radioactive seed implantation combined with microwave ablation.Results:The total effective rate of 125I radioactive seeds implantation combined with microwave ablation was 14/18(77.8%),the 3-month survival rate was 15/18(83.3%),the 6-month survival rate was 13/18(72.2%),the 9-month survival rate was 12/18(66.7%)and the 12-month survival rate was 11/18(61.1%).Conclusion:125I radioactive seeds implantation for the treatment of giant thymoma of chest(>7cm)requires multiple implantation,which has large radiation dose and more radiation-induced injury.125I radioactive seeds implantation combined with microwave ablation at the same time has the advantages of smaller radiation dose,less radiation-induced injury,fewer complications,better short-term efficacy,more obvious pain relief,and has become a new choice of treatment for giant thymoma of chest(>7cm).

关 键 词：125I放射性粒子植入 微波消融 胸部巨大胸腺瘤(>7㎝) 

分 类 号：R734.2[医药卫生—肿瘤]