消融治疗术后肝癌患者的相关生存质量研究  

Study on quality of life of patients with hepatocellular carcinoma after ablation therapy

作　　者：张淑红[1] 霍传红[1] Zhang Shuhong;Huo Chuanhong(Dezhou People's Hospital, Dezhou 253014, China)

机构地区：[1]德州市人民医院,253014

出　　处：《国际医药卫生导报》2019年第6期846-848,共3页International Medicine and Health Guidance News

基　　金：山东省医药卫生科技发展计划项目(2017WS870).

摘　　要：目的探讨射频消融术(RFA)治疗后,原发性肝癌(HCC)患者的短期生存质量。方法选取2017年12月至2018年6月间在本院接受治疗的HCC患者60例作为主要研究对象,均经肝穿刺病理活检确诊,按照随机数字表法将患者分为RFA组(n=40,采用RFA治疗)及对照组(n=20,采用手术切除),分析比较治疗前后两组肝功能指标、SF-36生存质量量表,随访观察6个月后两组患者术后复发及残留病灶情况等。结果与治疗前相比,两组治疗后肝功能指标及SF-36各维度评分均有明显改善(P<0.01);且RFA组治疗后ALB为(45.2±12.3)g/L、ALT为(94.6±17.2)U/L、Tbil为(22.6±7.3)μmol/L,显著优于对照组的[(39.8±11.7)g/L、(157.4±38.5)U/L、(28.6±8.7)μmol/L],两组比较差异均有统计学意义(均P<0.01);RFA组治疗后SF-36量表8个维度的评分均显著高于对照组(均P<0.01);随访6个月,RFA组复发率17.5%显著高于对照组的0.0%(P<0.05)。结论RFA术后HCC的患者肝功能及生活质量均有明显改善,但RFA术后的复发率高于手术组。Objective To investigate the short-term quality of life of patients with hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA). Methods From December 2017 to June 2018, 60 patients with HCC who were treated in our hospital were selected as the main subjects. All the patients were confirmed by liver biopsy and were divided into two groups according to the random number table. The RFA group (n=40) was treated with RFA, and the control group (n=20) was treated by surgical resection. Before and after treatment, the liver function indexes, SF-36 quality of life (QOL) score were compared between the two groups. After 6 months’ follow-up, the relapse and residual lesions were analyzed in the two groups. Results Compared with those before treatment, the liver function indexes and SF-36 scores of the two groups were significantly improved after treatment (P<0.01). The ALB of the RFA group after treatment was (45.2±12.3) g/L, the ALT was (94.6±17.2) U/L, the Tbil was (22.6±7.3)μmol/L, which were significantly superior to the control group [(39.8±11.7) g/L,(157.4±38.5) U/L,(28.6±8.7)μmol/L, P<0.01]. The scores of 8 dimension of SF-36 scale in the RFA group were significantly higher than those in the control group after treatment (P<0.01). After 6 months’ follow-up, the relapse rate in the RFA group was significantly higher than that in the control group (17.5% vs.0.0%, P<0.05). Conclusion After RFA, the liver function and quality of life of patients with HCC improved significantly, but the relapse rate of RFA was higher than that of operation group.

关 键 词：肝癌 射频消融术 生存质量 

分 类 号：R735.7[医药卫生—肿瘤]