盐酸多奈哌齐与茴拉西坦联合认知训练治疗血管性认知障碍的效果对比  

Comparison of the effects of donepezil hydrochloride and aniracetam combined with cognitive training in the treatment of vascular cognitive impairment

作　　者：陈小容[1] 喻明[1] 王秀容[1] 徐磊[1] 张运伟[1] 李琳琳[1] CHEN Xiao-rong;YU Ming;WANG Xiu-rong;XU Lei;ZHANG Yun-wei;LI Lin-lin(Suining Central Hospital,Suining 629000,Sichuan,China)

机构地区：[1]遂宁市中心医院,四川遂宁629000

出　　处：《川北医学院学报》2019年第1期106-109,共4页Journal of North Sichuan Medical College

摘　　要：目的:对比盐酸多奈哌齐与茴拉西坦联合认知训练治疗血管性认知障碍(vascular cognitive impairmen,VCI)的效果。方法:按照随机数字表法,将80例VCI患者分为盐酸多奈哌齐组和茴拉西坦组,每组各40例。两组分别采用盐酸多奈哌齐、茴拉西坦联合认知训练治疗3个月。对比两组治疗前后蒙特利尔认知功能(montreal cognitive function,MoCA)评分、日常生活质量评分、治疗效果、肝肾功能;并对比治疗期间不良事件发生情况。结果:治疗后,两组MoCA得分均高于治疗前(P<0.05),且盐酸多奈哌齐组高于茴拉西坦组(P<0.05);治疗后,两组工具性日常生活能力(IADL)、基本日常生活能力(BADL)得分及总分均低于治疗前(P<0.05),且盐酸多奈哌齐组显著低于茴拉西坦组(P<0.05);盐酸多奈哌齐组治疗总有效率高于茴拉西坦组(P<0.05);治疗前后两组谷丙转氨酶(ALT)、谷草转氨酶(AST)及血尿素氮(BUN)水平比较,差异无统计学意义(P>0.05);两组治疗期间的头晕、腹泻及睡眠障碍发生率及总发生率比较,差异无统计学意义(P>0.05)。结论:与茴拉西坦联合认知训练相比,盐酸多奈哌齐联合认知训练对改善VCI患者认知障碍及提高患者日常生活能力的效果更佳。Objective:To compare the effects of donepezil hydrochloride and aniracetam combined with cognitive training in the treatment of vascular cognitive impairment(VCI).Methods:80 patients with VCI were randomly divided into donepezil hydrochloride group and aniracetam group according to the random number table method,each group had 40 cases.The two groups were treated with donepezil hydrochloride and aniracetam combined with cognitive training for 3 months,respectively.Montreal Cognitive Function(MoCA) score,quality of daily life score,therapeutic effect,liver and kidney function were compared between the two groups before and after treatment,and adverse events during treatment were compared.Results:After treatment,the scores of MoCA in both groups were higher than those before treatment(P<0.05),and the scores in donepezil hydrochloride group were higher than those in aniracetam group(P<0.05).After treatment,the scores of instrumental activities of daily living(IADL),basic activities of daily living(BADL) and total scores of both groups were lower than those before treatment(P<0.05),and the scores of donepezil hydrochloride group were significantly lower than those of aniracetam group(P<0.05).The total effective rate of donepezil hydrochloride group was higher than that of aniracetam group(P<0.05).There was no significant difference in ALT,AST and BUN levels between the two groups before and after treatment(P>0.05).There was no significant difference in the incidence of dizziness,diarrhea,sleep disorders and total incidence between the two groups during treatment(P>0.05).Conclusion:Compared with aniracetam combined with cognitive training,donepezil hydrochloride combined with cognitive training has better effect on improving cognitive impairment and daily living ability of VCI patients.

关 键 词：盐酸多奈哌齐 茴拉西坦 认知训练 血管性认知障碍 

分 类 号：R743[医药卫生—神经病学与精神病学]