克罗恩病95例临床特点及治疗分析  

The Clinical Characteristics and Treatment Analyse of 95 Patients With Crohn's Disease

作　　者：张绅[1,2] 刘维新 ZHANG Shen;LIU Weixin(Department of Gastroenterology, The FirstHospital, China Medical University, Shenyang Liaoning 110001, China;Department of Gastrointestinal Endoscopy, The Fourth Hospital, ChinaMedical University, Shenyang Liaoning 110032, China)

机构地区：[1]中国医科大学附属第一医院消化科,辽宁沈阳110001 [2]中国医科大学附属第四医院消化内镜科,辽宁沈阳110032

出　　处：《中国继续医学教育》2019年第10期109-112,共4页China Continuing Medical Education

摘　　要：目的回顾性分析我院收治的95例克罗恩病(Crohn’s disease,CD)患者的临床特点及诊治情况,以提高对本病的诊断及治疗的理解,改善患者预后。方法按照2012年广州炎症性肠病诊断与治疗的共识意见,对我院2009年10月—2018年6月95例CD住院患者一般资料、临床表现、误诊情况及治疗药物等资料进行总结及回顾性分析。结果克罗恩病高发于年轻人,可侵犯消化道任一部位,临床表现多样,主要以腹痛、腹泻为主要肠道症状,肠道病变呈多部位性,可致多种肠内外并发症,导致临床症状复杂与多样化,误诊率高,治疗上以糖皮质激素、免疫抑制剂及氨基水杨酸为主要药物,而IFX对于激素依赖及激素抵抗的CD患者有效。结论克罗恩病表现多样,容易误诊为其他疾病,诊断需要结合临床表现、内镜、影像学和病理组织学进行综合分析并随访观察。治疗以内科治疗为主,外科治疗主要针对有并发症患者。Objective To analyze the clinical features, diagnosis and treatment of patients with Crohn’s disease(CD), in order to improve the understanding of the diagnosis and treatment of this disease and improve the prognosis of patients. Methods According to the Guangzhou 2012 consensus diagnosis and treatment of inflammatory bowel disease, the general data, clinical manifestations, misdiagnosis and therapeutic drugs of 95 CD inpatients in our hospital from October 2009 to June 2018 were summarized and retrospectively analyzed. Results Crohn’s disease was highly prevalent in young people and could invade any part of the digestive tract. The clinical manifestations were diverse. The main symptoms are abdominal pain and diarrhea. The intestinal lesions were multi-site and could cause a variety of intestinal and internal complications. The clinical symptoms were complex and diversified, and the rate of misdiagnosis was high. The treatment was based on glucocorticoids, immunosuppressive agents and aminosalicylic acid, and IFX was effective for CD patients with hormone dependence and hormone resistance. Conclusion Crohn’s disease is diverse and easily misdiagnosed as other diseases. The diagnosis needs to be combined with clinical manifestations, endoscopy, imaging and histopathology for comprehensive analysis and follow-up observation. The treatment is mainly based on medical treatment, and the surgical treatment is mainly for patients with complications.

关 键 词：克罗恩病 临床特征 免疫抑制剂 治疗 

分 类 号：R573[医药卫生—消化系统]