非小细胞肺癌患者N2组淋巴结转移相关因素分析和淋巴结清除范围选择  

Related factors of N2 lymph node metastasis in non-small cell lung cancer and selection of lymph node dissection

作　　者：蔡磊[1] 梁津逍[1] 陈倩[1] 杨迅[1] 蒋友华[1] Cai Lei;Liang Jingxiao;Chen Qian;Yang Xun;Jiang Youhua(Department of Thoracic Surgery,Zhejiang Cancer Hospital,Hangzhou 310000,China)

机构地区：[1]浙江省肿瘤医院胸外科,杭州310000

出　　处：《中国医师杂志》2019年第2期232-234,238,共4页Journal of Chinese Physician

摘　　要：目的分析非小细胞肺癌患者N2组淋巴结转移相关因素,探讨N2组淋巴结采样或清除的适宜人群。方法回顾性分析本院胸外科2014年7月至2016年5月期间110例非小细胞肺癌患者的临床资料,统计与淋巴结转移的可能相关因素并分析。结果单因素分析显示,肿瘤最长径> 2 cm(P=0. 016)、淋巴结显影(P=0. 021)、胸膜受累(P=0. 002)为N2组淋巴结转移相关因素,同时具有三个相关因素为N2组淋巴结转移独立相关因素。结论肿瘤最长径、淋巴结显影、胸膜受累为N2淋巴结转移相关因素,对于同时有3个相关因素患者,强烈建议行系统性淋巴结清除。Objective To analyze the related factors of lymph node metastasis in N2 group of patients with non-small cell lung cancer, and found its meaning for lymph node dissection. Methods A retrospective analysis was made on 110 patients with non-small cell lung cancer from July 2014 to May 2016 in our thoracic surgery department. Potential related factors were collected, single factor analysis and variate analysis were carried out to find the relationship between N2 lymph node metastasis and potential related factors. Results Univariate analysis showed that the longest diameter of the tumor >2 cm (P=0.016), lymph node imaging (P=0.021), pleural involvement (P=0.002) were related factors of lymph node metastasis in N2 group, and these three factors were independent related factors of lymph node metastasis in N2 group. Conclusions The longest diameter of the tumor, lymph node imaging and pleural involvement are related factors of N2 lymph node metastasis. Systematic lymph node dissection is strongly recommended for patients with three related factors at the same time.

关 键 词：癌 非小细胞肺 淋巴转移 危险因素 淋巴结切除术 

分 类 号：R734.2[医药卫生—肿瘤]