注射型富血小板纤维蛋白在上颌窦外提升术中的应用效果  

Bone regeneration effect of injectable-platelet rich fibrin(I-PRF) in lateral sinus lift:a pilot study

作　　者：谢慧[1] 解永富[1] 刘勤[1] 商玲燕[1] 陈敏箴[1] XIE Hui;XIE Yong-fu;LIU Qin;SHANG Ling-yan;CHEN Min-zhen(Department of Implantology,Changzhou Stoni otologic alHospital. Changzhou 213003,Jiangsu Province,China)

机构地区：[1]常州市口腔医院种植科,江苏常州213003

出　　处：《上海口腔医学》2019年第1期71-75,共5页Shanghai Journal of Stomatology

摘　　要：目的 :评价注射型富血小板纤维蛋白(injectable-platelet rich fibrin,I-PRF)在上颌窦外提升术中促进成骨的效果。方法:选取2014年6月—2015年6月就诊于江苏省常州市口腔医院种植科,上颌后部磨牙或前磨牙单颗缺失可用骨高度3～5 mm,需进行上颌窦外提升的患者46例,随机分为2组,A组窦底填塞Bio-oss骨粉,B组窦底填塞Bio-oss骨粉+I-PRF混合物。拍摄锥形束CT(CBCT),于术前测量剩余骨高度(residual bone height,RBH),术后即刻、术后6个月、术后12个月测量新生骨高度(new formed bone height,NFBH),并于术后4个月进行二期手术,术后6个月修复时测量ISQ值,比较2组成骨效果。采用SPSS 20.0软件包对数据进行统计学分析。结果:46例患者伤口均一期愈合,无感染、裂开等。CBCT检查显示,术前、术后12个月2组间RBH比较差异无统计学意义(P>0.05),术后即刻、术后6个月,A组RBH显著高于B组(P<0.05)。术后4个月,A组ISQ值显著高于B组(P<0.05),而术后6个月2组ISQ值无显著差异(P>0.05)。结论:I-PRF在上颌窦底外提升术中安全可靠,能够有效缩短愈合时间,增强成骨效果。PURPOSE: The aim of the present research was to evaluate the regeneration effect of injectable-platelet rich fibrin(I-PRF) in lateral sinus lift. METHODS: A total of 46 cases, who lost their single posterior tooth with residual bone height of 3-5 mm, who needed lateral sinus lift, were treated in our hospital for implantation from June 2014 to Jun 2015.They were randomly divided into 2 groups. In group A, Bio-oss was used as a sole grafting material to fill the sinus;in group B, Bio-oss was used in combination with I-PRF to fill the sinus. Cone-beam CT(CBCT) was taken preoperatively,the residual bone height(RBH) was measured. The new formed bone height(NFBH) was measured immediately, 6 months and 12 months after surgery. ISQ values of implants were taken 4 months, 6 months postoperatively. SPSS 20.0 software was used for statistical analysis. RESULTS: All cases achieved primary healing, no infection or dehiscence was found. No significant difference of the RBH and NFBH was found between pre-operation or 12 months postoperatively, while significant difference was found immediately and 6 months postoperatively. The value of ISQ in group A was significantly higher than that in group B at 4 months(P<0.05), and there was no significant difference between 2 groups 6 months after operation(P>0.05). CONCLUSIONS: I-PRF is a safe and reliable material in sinus lift, which can effectively shorten the healing time and enhance the effect of osteogenesis.

关 键 词：上颌窦外提升 注射型富血小板纤维蛋白 骨再生 

分 类 号：R782.1[医药卫生—口腔医学]