慢性脑灌注不足与血管性认知损害  

Chronic cerebral hypoperfusion and vascular cognitive impairment

作　　者：孙美 侯晓夏 程虹[1] Sun Mei;Hou Xiaoxia;Cheng Hong(Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China;Department of Neurology, Suzhou Municipal Hospital, Suzhou 215000, China)

机构地区：[1]南京医科大学第一附属医院神经内科,210029 [2]苏州市立医院神经内科,215000

出　　处：《国际脑血管病杂志》2018年第12期921-926,共6页International Journal of Cerebrovascular Diseases

基　　金：江苏省人社厅“六大人才高峰”资助项目(WSN-025).

摘　　要：慢性脑灌注不足(chronic cerebral hypoperfusion, CCH)是导致血管性认知损害(vascular cognitive impairment, VCI)的重要因素,与无症状脑梗死、脑白质疏松等小血管病变密切相关。VCI具体机制尚未明确,CCH表现也存在较大差异。文章从动物模型、灌注表现、病理生理学机制等方面对CCH与VCI的关系进行了综述。Chronic cerebral hypoperfusion (CCH) is an important factor leading to vascular cognitive impairment (VCI). It is closely related to small vessel disease such as asymptomatic cerebral infarction and leukoaraiosis. The specific mechanism of VCI remains unclear. The manifestations of CCH are also quite different. This article reviews the relationship between CCH and VCI from animal models, perfusion performance, and pathophysiological mechanisms, etc.

关 键 词：脑血管障碍 脑血管循环 认知障碍 危险因素 时间因素 

分 类 号：R749.13[医药卫生—神经病学与精神病学]