红系增生髓系肿瘤的诊断分类演变  

Advances in diagnostic classification of erythroid proliferations in myeloid neoplasms

作　　者：盛俊杰 万岁桂[1] Sheng Junjie;Wan Suigui(Department of Hemaiology,Xuanum Hospital,Capital Medical University,Beijing J00053,China)

机构地区：[1]首都医科大学宣武医院血液科,北京100053

出　　处：《白血病．淋巴瘤》2019年第2期125-128,共4页Journal of Leukemia & Lymphoma

摘　　要：红系增生髓系肿瘤(MN-EP)是一组异质性疾病,以骨髓中有核红细胞增殖、无效造血为主要特点。最初,法、美、英分型(FAB分型)依据形态学标准对MN-EP进行诊断分类。但随着流式细胞术、细胞遗传学及分子生物学技术的发展,FAB分型存在明显不足,不能满足临床需求。因此,世界卫生组织(WHO)分类出台了更准确的诊断分类标准,并对其进行了多次修订。文章对MN-EP诊断分类演变作一综述。Erythroid proliferations in myeloid neoplasms (MN-EP) is a group of heterogeneous diseases characterized by nucleated red blood cell proliferation and ineffective hematopoiesis in the bone marrow. Initial French-American-British (FAB) classification was used to diagnose and classify MN-EP according to morphological criteria. However, with the development of flow cytometry, cytogenetics and molecular biology techniques, FAB classification is obviously insufficient, which can not meet the clinical needs. Therefore, the World Health Organization (WHO) classification has introduced more accurate diagnostic classification standards and revised them several times. This paper reviews the research progress of MN-EP diagnostic classification.

关 键 词：红系增生髓系肿瘤 法、美、英分型 世界卫生组织分类 

分 类 号：R733.3[医药卫生—肿瘤]