跨膜6超家族成员2 rs58542926单核苷酸多态性的研究进展  

Research progress of single-nucleotide polymorphism in theTM6SF2 rs58542926

作　　者：李媛[1] 孙欣 战淑慧[1] 高玉强[1] 辛永宁[2] 宣世英[2] Li Yuan;Sun Xin;Zhan Shuhui;Gao Yuqiang;Xin Yongning;Xuan Shiying(Department of Gastroenterology,Qingdao Municipal Hospital,Qingdao 266000,China;Department of Gastroenterology II,Qingdao Municipal Hospital,Qingdao 266000,China)

机构地区：[1]青岛市市立医院消化科,266000 [2]青岛市市立医院消化科内二科,266000

出　　处：《中华肝脏病杂志》2019年第3期223-226,共4页Chinese Journal of Hepatology

基　　金：山东省重点研发计划项目(2016GSF201217);山东省医药卫生科技发展计划项目(2015WS0321);青岛市市南区科技发展资金(2015-6-014-YY);国家自然科学基金面上项目(31770837).

摘　　要：跨膜6超家族成员2(TM6SF2)是近些年来被发现的一个基因,该基因定位于第19号染色体上(19p12),编码由351个氨基酸构成的蛋白。目前有很多研究报道TM6SF2 rs58542926的单核苷酸多态性与血脂、非酒精性脂肪肝、心血管病、肝癌、丙型肝炎等疾病的发病、发展都有密切的关系,现就这些方面的研究进展进行综述。Transmembrane 6 superfamily member 2(TM6SF2)is a recently discovered gene,which is located on the chromosome 19(19p12)and encodes a protein consisting of 351 amino acids.Presently,many studies have reported that the single-nucleotide polymorphism of TM6SF2 rs58542926 and plasma lipids are closely related to the incidence and development of diseases,such as non-alcoholic fatty liver disease(NAFLD),cardiovascular disease(CVD),liver cancer,and hepatitis C.This review will summarize the research progress conducted in these areas.

关 键 词：单核苷酸多态性 脂肪肝 非酒精性 血脂 跨膜6超家族成员2 

分 类 号：R575[医药卫生—消化系统]