肠道菌群与孤独症谱系障碍关系的研究进展  

Advance in Relationship between Autism Spectrum Disorders and Microbiome(review)

作　　者：张春艳[1,2] 朱路文[1,2] 唐强[1,2] ZHANG Chun-yan;ZHU Lu-wen;TANG Qiang(Rehabilitation Medical College, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China;The Second Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150001, China)

机构地区：[1]黑龙江中医药大学第二临床医学院,黑龙江哈尔滨市150040 [2]黑龙江中医药大学附属第二医院,黑龙江哈尔滨市150001

出　　处：《中国康复理论与实践》2019年第3期319-323,共5页Chinese Journal of Rehabilitation Theory and Practice

基　　金：黑龙江中医药大学科研基金项目(No.201517);黑龙江中医药大学附属第二医院科研基金项目(No.YM-201704)~~

摘　　要：随着微生物与大脑相互作用研究的深入,越来越多的科学家认识到肠道菌群对孤独症谱系障碍(ASD)患儿大脑和行为的重要性。目前,主要的研究集中于探究肠道微生物对ASD的致病机制。肠道微生物组与中枢神经系统的双向调节主要通过调节单胺类神经递质、下丘脑-垂体-肾上腺轴激活和神经免疫激活等途径来实现。微生物-肠-脑轴失衡可影响行为表型,导致ASD。因此,通过调节肠道微生物组来治疗ASD是今后的研究热点。本文对ASD肠道微生物组的研究现状进行总结,为肠道微生物组对神经心理的调控寻找更多的证据,以便能更好地理解微生物-肠-脑轴的潜在机制。It has been increasingly recognized that the presence of a healthy and diverse gut microbiota is important to the development of central nervous system and emotional processing for children with autism spectrum disorders (ASD). The inter-connection of gut microbiome and brain function has significantly contributed to establishing the microbiota-gut-brain axis as an extension of the well-accepted gut-brain axis concept. The bidirectional interaction between the gut microbiota and the brain occurs through various pathways including serotonin, hypothalamus-pituitary-adrenal axis, neurotrophin, and the immune system. The microbiota-gut-brain axis has been shown to influence the behaviors associated with neuro-psychiatric conditions. Modulation of this gut microbiota as a novel therapy for ASD is gaining interest. This paper summarized the status of neuropsychological microbiome, which provided evidence supporting the role of gut microbiota in modulating neuropsychological functions of the central nervous system and exploring the potential underlying mechanisms .

关 键 词：孤独症谱系障碍 微生物-肠-脑轴 综述 

分 类 号：R749.93[医药卫生—神经病学与精神病学]