帕金森病患者的血脂水平及其相关性  

Relationship between Serum Lipid Levels and Parkinson's Disease

作　　者：于鸿远 何景华 刘双 孙丽娟[1] 殷雁[1] YU Hong-yuan;HE Jing-hua;LIU Shuang;SUN Li-juan;YIN Yan(Neurology Department, the Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, China)

机构地区：[1]大连医科大学附属第二医院神经内科,辽宁大连市116027

出　　处：《中国康复理论与实践》2019年第3期352-356,共5页Chinese Journal of Rehabilitation Theory and Practice

基　　金：国家自然科学基金青年基金项目(No.81801173);辽宁省自然科学基金面上项目(No.20180550891)~~

摘　　要：目的探究血脂与帕金森病的关系以及对帕金森病的预测价值。方法 2016年1月至2018年11月,帕金森病患者145例为患者组,同期122例健康体检者为对照组,检测血脂水平,分析各项血脂指标与帕金森病病程、疾病严重程度和运动分型的相关性,计算相关血脂指标的预测值。结果患者组总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1 (ApoA1)、载脂蛋白B (ApoB)均低于对照组(t> 2.089, P <0.05);Logistic回归分析显示,ApoA1是患帕金森病的保护因素(OR=0.081, P <0.01)。ApoA1的最佳截取阈值为1.38 mmol/L,敏感度性0.72,特异性0.68。结论帕金森病患者总体血脂水平低于健康人,低ApoA1可能是帕金森病发病的潜在独立危险因素,可以作为预测帕金森病患病风险的参考。Objective To investigate the relationship between serum lipids and Parkinson's disease, and its predictive value for Par-kinson's disease. Methods From January, 2016 to November, 2018, 145 patients with Parkinson's disease and other 122 healthy subjects were selected. They were measured the various lipid indexes. Results Total cholesterol, low density lipoprotein cholesterol, Apolipoprotein A1 (ApoA1) and Apolipoprotein B (ApoB) were less in the patients than in the controls (t > 2.089, P < 0.05). ApoA1 was an independent protective factor from Logistic regression (OR = 0.081, P < 0.01). The most optimal cutoff threshold of ApoA1 was 1.38 mmol/ L, with the sensitivity of 0.72 and the specificity of 0.68. Conclusion The lipid decreased in patients with Parkinson's disease. Low ApoA1 may be a potential independent risk factor for Parkinson's disease, which may be a predictor for it.

关 键 词：帕金森病 血脂 载脂蛋白A1 相关性 

分 类 号：R742.5[医药卫生—神经病学与精神病学]