帕罗西汀联合舒肝解郁胶囊治疗产后抑郁临床研究  

Clinical study of paroxetine combined with Shuganjieyu capsule in the treatment of postpartum depression

作　　者：陈丽珍[1] 徐晓英 忽平[1] Chen Lizhen;Xu Xiaoying;Hu Ping(Nanyang Central Hospital,Nanyang 473009,Henan,China)

机构地区：[1]南阳市中心医院,河南南阳473009

出　　处：《临床心身疾病杂志》2019年第2期96-98,109,共4页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨帕罗西汀联合疏肝解郁胶囊治疗产后抑郁患者临床疗效以及对生存质量的影响.方法将60例产后抑郁患者按随机数字表法分为观察组与对照组,每组30例,均予以口服帕罗西汀治疗,观察组在此基础上联合疏肝解郁胶囊治疗,观察6周.治疗前后采用汉密顿抑郁量表评定临床疗效,世界卫生组织生存质量测定量表简表评定生存质量.结果治疗后两组汉密顿抑郁量表评分均较治疗前显著下降(P<0.01),且治疗各时点观察组评分显著低于对照组(P<0.05或0.01);观察组治疗后世界卫生组织生存质量测定量表简表各维度评分均较治疗前显著升高(P<0.01),对照组仅生理领域、综合平均评分较治疗前显著升高(P<0.05),观察组世界卫生组织生存质量测定量表简表各维度评分显著高于对照组(P<0.05或0.01);治疗6周末观察组改善抑郁症状总有效率(93.33%)显著高于对照组(66.67%)(P<0.05).结论帕罗西汀联合疏肝解郁胶囊治疗产后抑郁患者具有协同增效作用,能显著缓解抑郁症状,提高生存质量,显著优于单用帕罗西汀治疗.Objective To investigate the clinical efficacy of paroxetine combined with Shuganjieyu capsule in the treatment of postpartum depression and its impact on quality of life.Methods 60 patients with postpartum depression were randomly divided into the control group and the observation group,30 cases in each group.All were treated with oral paroxetine,and the observation group was treated with Shuganjieyu capsule on the basis of this observation for 6 weeks.The Hamilton Depression Scale(HAMD)was used to evaluate the clinical efficacy before and after treatment.The World Health Organization's Quality of Life Questionnaire-Brief Version(WHOQOL-BRIEF)was used to evaluate patients life quality.Results After treatment,the scores of the Hamilton Depression Scale were significantly lower than those before treatment(P<0.01),and the scores of the observation group at each time point were significantly lower than those of the control group(P<0.05 or 0.01).The scores of WHOQOL-BRIEF in the observation group were significantly higher than those before treatment(P<0.01).In the control group,only the physiological field and the comprehensive average score were significantly higher than before treatment(P<0.05).The scores of WHOQOL-BRIEF in the observation group were significantly higher than those in the control group(P<0.05 or 0.01).At the end of the 6th week,the total effective rate of improvement of depressive symptoms in the observation group(93.33%)was significantly higher than that in the control group(66.67%)(P<0.05).Conclusion Paroxetine combined with Shuganjieyu Capsule has synergistic effect in the treatment of postpartum depression,which can significantly alleviate depressive symptoms and improve quality of life,which is significantly better than paroxetine alone.

关 键 词：产后抑郁 疏肝解郁胶囊 帕罗西汀 生存质量 汉密顿抑郁量表 世界卫生组织生存质量测定量表简表 

分 类 号：R749.4[医药卫生—神经病学与精神病学]