气滞胃痛颗粒联合雷贝拉唑及叶酸治疗慢性萎缩性胃炎的疗效评价  

Therapeutic Efffect of Qizhiiweitong Granule Combined with Rabeprazole and Folic Acid in The Treatment of Chronic Atrophic Gastritis

作　　者：王茜 WANG Qian(Department of traditional Chinese medicine.Shenyang Second Traditional Chinese Medicine Hospital. Shenyang 110101,Liaoning Provincc,China)

机构地区：[1]沈阳市第二中医医院中药局,沈阳110101

出　　处：《中国实用乡村医生杂志》2019年第3期45-48,共4页Chinese Practical Journal of Rural Doctor

摘　　要：目的研究气滞胃痛颗粒联合叶酸治疗慢性萎缩性胃炎(CAG)的临床效果。方法选取2015年4月2017年4月在沈阳市第二中医医院就诊的60例CAG患者作为研究对象,随机分为观察组和对照组各30例。对照组采用雷贝拉唑联合叶酸治疗,观察组在对照组用药基础上加以气滞胃痛颗粒治疗,比较两组的治疗效果、临床检测指标及胃镜病理分级评分。结果两组胃泌素在血清中的含量、血清CD4+T细胞比例及血清CD4+T/CD8+T值在治疗后均有提高,差异有统计学意义(P<0.05);血清中可体性白细胞介素2(sIL-2R)含量、血清CD8+T细胞占总细胞数的比例在治疗后均降低,差异有统计学意义(P<0.05)。观察组治疗有效率高于对照组,差异有统计学意义(P<0.05)。结论气滞胃痛颗粒联合雷贝拉唑及叶酸治疗慢性萎缩性胃炎效果较好,值得推广使用。Objective To study the effect of Qizhiweitong Granule combined with folic acid in the treatment of chronic atrophic gastritis(CAG).Methods Sixty paticnts with CAG in our department were enrolled in this study.They were randoinly divided into observation group(n=30)and control group(n=30).Both groups were treated with rabeprazole and folic acid,while the observation group was treated with Qizhiweitong Granule.The therapeutic effect,clinical indexes,and pathological grading score were compared between two groups.Results There were significant differences in serum gastrin(GAS)levels,serum CD4+cell and serum CD4+T/CD8+T ratio between before and after treatment(P<0.05).The scrum sIL-2R content and the ratio of senim CD8+T cells/total cells were significantly decreased after treatment(P<0.05).The effective rate in observation group was significantly higher than control group(P<0.05).Conclusion Qizhiweitong Granule combined with rabeprazole and folic acid is effective in the treatment of CAG and can be further clinically promoted.

关 键 词：气滞胃痛颗粒 叶酸 慢性萎缩性胃炎 血清胃泌素含量 可溶性白细胞介素2 

分 类 号：R573[医药卫生—消化系统]