Serum apelin predicts spontaneous reperfusion of infarct-related artery in patients with ST-segment elevation myocardial infarction  

作　　者：ZHOU Ying 周颖(Coronary Heart Center,China-Japan Friendship Hosp)

机构地区：[1]Coronary Heart Center,China-Japan Friendship Hosp

出　　处：《China Medical Abstracts(Internal Medicine)》2018年第4期220-221,共2页中国医学文摘（内科学分册（英文版）

摘　　要：Objective To assess whether serum Apelin correlates with spontaneous reperfusion(SR)of the infarct-related artery(IRA)in STEMI patients.Methods Blood samples were obtained on admission and before p PCI in 280 consecutive STEMI patients,who were hospitalized in China-Japan Friendship Hospital between January 2016 and December 2016.Blood chemistry,Apelin level were examined.Coronary arteriography and echocardiography were performed after admission.Patients were divided into SR(TIMI 2-3,n=57)and non-SR(TIMI 0-1,n=223)groups according to TIMI results.Logistic regression analysis was performed to define the independent predictors of SR.Results Prevalence of smoking and pathoglycemia(including diabetes,impaired glucose tolerance and impaired fasting glucose)was significantly higher in the non-SR group than in the SR group(both P<0.05).Peak values of plasma troponin-I and percent of the patients with Killip 2 ~ 3 were significantly higher in non-SR group than in SR group(P<0.05).Left ventricular systolic and diastolic functions were remarkably improved in SR group compared with non-SR group.Gensini scores were lower in the SR-group than the non-SR group(P=0.02).Serum Apelin was significantly higher in patients with SR compared to patients with non-SR([0.82±0.34] ng/ml vs [0.35±0.22] ng/ml,P=0.04).A cut off Apelin value of 0.75 ng/ml had a predictive value of 77% to identify patients with SR(sensitivity=81%).Logistic regression analysis showed that serum Apelin level is an independent predictor of SR(OR=2.18,95% CI:1.10-4.33,P=0.01)for STEMI patients.Conclusion Patients with SR have better cardiac systolic function and diastolic func-tion.An increased serum Apelin level is an independent and novel predictor of SR for STEMI patients.Detection of serum Apelin level is helpful to predict SR in STEMI patients.

关 键 词：CORONARY ARTERIOGRAPHY ECHOCARDIOGRAPHY 

分 类 号：R[医药卫生]