术前系统免疫炎症指数和反应蛋白/血清白蛋白比值与非小细胞肺癌预后的相关性  

Prognostic values of preoperative systematic immue-inflammation index and CRP/Alb in non-small cell lung cancer patients

作　　者：张辉 施仲义[1] 胡一迪[1] 谢燊侠 ZHANG Hui;SHI Zhong-yi;HU Yi-di;XIE Shen-xia(Second Surgical Department, Wenzhou Hospital of Traditional Chinese Medicine, Wenzhou, Zhejiang 325000, China)

机构地区：[1]温州市中医院外二科,浙江温州325000

出　　处：《中国卫生检验杂志》2019年第5期573-576,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨术前系统免疫炎症指数(SII)和C-反应蛋白/血清白蛋白比值(CRP/Alb)与非小细胞肺癌(NSCLC)预后的相关性。方法回顾性分析2012年1月-2015年12月本院收治的124例NSCLC手术患者的临床资料,分析术前SII和CRP/Alb与临床病理特征及预后之间的关系。结果 SII低水平组与高水平组在性别、年龄、病理分型上差异无统计学意义(P>0.05),但SII高水平组的TNM分期、T分期及N分期均较晚,KPS评分也较低(P<0.05)。与CRP/Alb低水平组比较,CRP/Alb高水平组的TNM分期、T分期、N分期和KPS评分亦较晚或较低(P<0.05),2组患者之间的其他病理特征比较差异无统计学意义(P>0.05)。SII低水平组和高水平组的中位生存时间分别为38.2个月和21.0个月,差异有统计学意义(P=0.01)。CRP/Alb组低水平组和高水平组的中位生存时间分别为43.5个月和19.6个月,差异有统计学意义(P<0.01)。Cox多因素分析结果显示,TNM分期、KPS评分、术前SII和CRP/Alb是NSCLC预后的独立危险因素(P<0.05)。结论术前SII和CRP/Alb均是影响NSCLC预后的独立危险因素,SII和CRP/Alb升高提示预后不良。Objective To investigate the prognostic values of preoperative systematic immue-inflammation index(SII) and C-reactive protein/albumin ratio(CRP/Alb) in non-small cell lung cancer patients(NSCLC). Methods The clinical data of 124 cases with NSCLC were reviewed. The relationship of preoperative SII and CRP/Alb with clinicopathological features and prognosis was analyzed during January 2012-December 2015. Results There was no statistical significance on the differences in gender, age and pathological classification between low SII group and high SII group(P>0.05). However, the TNM stage, T stage and N stage of high SII group were relatively later, and KPS score was also lower(P<0.05). Compared with low CRP/Alb group, TNM stage, T stage, N stage and KPS score of high CRP/Alb group were also later or lower(P<0.05). The difference in other clinicopathological features between low CRP/Alb group and high CRP/Alb group was not statistically significant(P>0.05). The median overall survival time of low SII group and high SII group were respectively 38.2 and 20.0 per month, with the differences statistically significant(P<0.05). Meanwhile, the median overall survival time of low CRP/Alb group and high CRP/Alb group were respectively 43.5 and 19.6 per month, with the differences statistically significant(P<0.05). Cox multivariate analysis showed that TNM staging, KPS score, preoperative SII and CRP/Alb were independent risk factors for NSCLC(P<0.05). Conclusion High level of preoperative SII and CRP/Alb were independent risk factors for poor prognosis of NSCLC.

关 键 词：非小细胞肺癌 系统免疫炎症指数 C-反应蛋白 白蛋白 预后 

分 类 号：R734.2[医药卫生—肿瘤]