Synthesis of 2,3-Fused Indoline Aminals via 4+2 Cycloaddition of NH-free Benzazetidines with Indoles  

作　　者：Zibo Bai Huarong Tong Hao Wang Gong Chen Gang He 

机构地区：[1]State Key Laboratory and Institute of Elemento-Organic Chemistry,College of Chemistry,Nankai University,Tianjin 300071,China [2]Collaborative Innovation Center of Chemical Science and Engineering (Tianjin),Tianjin 300071,China

出　　处：《Chinese Journal of Chemistry》2019年第2期119-125,共7页中国化学（英文版）

基　　金：the National Natural Science Foundation of China (Nos. 21502098, 21672105);the Natural Science Foundation of Tianjin (17JCYBJC19700);the Qindao National Laboratory for Marine Scie nee and Tech no logy, and the State Key Laboratory of Elemento-Organic Chemistry at Nankai University for financial support of this work.

摘　　要：Summary of main observation and conclusion A 4+2 cycloaddition reaction of NH-free benzazetidines with indoles under the catalysis of camphorsulfonic acid was developed. This method shows a broad substrate scope of benzazetidines and indoles, and offers a convenient method for stereoselective synthesis of various cis-2,3-fused indoline aminals. Preliminary mechanistic studies suggest the reaction proceed via a stepwise pathway featuring an electrophilic attack on the benzylic carbon of benzazetidine.

关 键 词：Synthesis of 2 3-Fused INDOLINE AMINALS 4+2 CYCLOADDITION of NH-free Benzazetidines with INDOLES 

分 类 号：O6[理学—化学]