地五养肝方联合熊去氧胆酸治疗原发性胆汁性胆管炎临床分析  

The Clinical Analysis of Diwu Yanggan Decoction Combined with Ursodeoxycholic Acid in the Treatment of Primary Biliary Cholangitis

作　　者：陆定波[1,2] 江诗怡 高翔 叶之华[1,2] 李瀚旻 LU Ding-bo;JIANG Shi-yi;GAO Xiang;YE Zhi-hua;LI Han-min(LI Han - min's Inheritance Studio of Old Chinese Medicineof Hubei Traditional Chinese Medicine Hospital ( Wuhan Hubei ,430061 ) China)

机构地区：[1]湖北省中医院李瀚旻名老中医传承工作室,湖北武汉430061 [2]湖北省中医药研究院中医理论传承创新中心中医基础理论研究所 [3]湖北中医药大学

出　　处：《中西医结合肝病杂志》2019年第1期13-15,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：国家自然科学基金项目(No.81373513);国家中医临床研究基地(湖北)重点病种研究项目(No.JDZX2012054;No.JDZX2015172);李瀚旻名老中医传承工作室资助项目(No.鄂卫生计生办通[2018]32号)

摘　　要：目的:基于真实世界临床数据,观察体现"补肾生髓成肝"治疗法则的地五养肝方治疗原发性胆汁性胆管炎(PBC)的临床疗效。方法:回顾性收集2014年1月至2018年6月在我院诊疗的71例PBC患者临床资料,其中采用地五养肝方联合熊去氧胆酸(UDCA)治疗的38例为治疗组,采用UDCA治疗的33例为对照组。治疗24周时,观察并比较两组患者治疗前后各生化指标(ALT、AST、GGT、TBil、ALP)、肝脏硬度值、证候积分变化,并比较两组患者的临床疗效。结果:两组患者治疗后ALT、AST、GGT、TBil、ALP水平、肝脏硬度值、证候积分与本组治疗前比较,差异均有显著性意义(P<0.05);治疗后治疗组患者在完全反应、部分生化指标(GGT、TBil)改善、肝脏硬度值下降、证候积分减少方面均优于对照组,差异有显著性意义(P<0.05),其临床疗效优于对照组。结论:体现补肾生髓成肝治疗法则的地五养肝方治疗PBC患者具有良好的临床效果。Objective:To observe the clinical efficacy of Diwu Yanggan Decoction(DWYG) in treating primary biliary cholangitis(PBC) based on the real world clinical data.Methods:The clinical data of 71 PBC patients diagnosed and treated in our hospital from 2014 to 2018 were retrospectively collected.Among them,38 cases were treated with Diwu Yanggan Decoction combined with ursodeoxycholic acid(UDCA) as treatment group and 33 cases were treated with UDCA as control group.At 24 weeks of treatment,the changes of biochemical indexes(ALT,AST,GGT,TBil,ALP),liver hardness and syndrome scores were observed and compared between the two groups before and after treatment,and the clinical efficacy of the two groups was compared.Results:After treatment,the levels of ALT,AST,GGT,TBil,ALP,liver stiffness and syndrome scores in each group were significantly different from those before treatment(P< 0.05).After treatment,the patients in the treatment group were better than those in the control group in terms of complete response,improvement of some biochemical indicators(GGT,TBil),decrease of liver hardness value and decrease of syndrome integral.The difference was significant(P<0.05).The clinical efficacy of the treatment group was better than that of the control group.Conclusion:Diwuyanggan Decoction,which embodies the therapeutic principle of invigorating kidney,promoting marrow and forming liver,has good clinical effect in treating PBC patients.

关 键 词：原发性胆汁性胆管炎 补肾生髓成肝法 地五养肝方 熊去氧胆酸 中西医结合治疗法 

分 类 号：R575.7[医药卫生—消化系统]