大承气汤联合奥曲肽治疗术后早期炎性肠梗阻疗效和安全性分析  

Effect and Safety of Dachengqi Decoction Combined with Octreotide in Treating Postoperative Early Obstructive Intestinal Obstruction

作　　者：王军[1] 张文胜 裴效瑞[1] 连镇 WANG Jun;ZHANG Wensheng;PEI Xiaorui;LIAN Zhen(Department of General Surgery,Tianjin TEDA Hospital,Tianjin 300457 , China)

机构地区：[1]天津市泰达医院普外科,天津300457

出　　处：《辽宁中医杂志》2019年第3期567-570,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:探究大承气汤联合奥曲肽治疗术后早期炎性肠梗阻疗效和安全性。方法:将2012年12月—2017年12月期间本院87例腹部手术后早期炎性肠梗阻患者随机分成两组,观察组采用大承气汤联合奥曲肽治疗,对照组采用大承气汤治疗,比较两组的临床疗效,症状缓解时间,血清炎症因子水平以及不良反应等。结果:观察组与对照组治疗1个疗程后的临床总有效率分别为95. 45%以及79. 09%,观察组明显高于对照组,比较差异具有显著性(P <0. 05);观察组患者的肠鸣音恢复时间、恢复排便时间、恢复排气时间均明显短于对照组,比较差异具有显著性(P <0. 05);治疗后,观察组的血清IL-6、IL-8以及TNF-α水平明显低于对照组,比较差异具有显著性(P <0. 05)。结论:大承气汤联合奥曲肽治疗腹部手术术后早期炎性肠梗阻促进了临床症状的缓解,提高了临床疗效,降低了机体炎症反应,安全性好。Objective: To investigate the efficacy and safety of Dachengqi Decoction combined with octreotide in the treatment of early postoperative inflammatory bowel obstruction. Methods: From December 2012 to December 2017,87 patients with early inflammatory bowel obstruction after abdominal surgery in our hospital were randomly divided into two groups. The observation group was treated with Dachengqi Decoction and octreotide,and the control group was treated with Dachengqi Decoction. Results: The clinical total effective rates of the observation group and the control group after treatment for one course of treatment were 95. 45%and 79. 09%,respectively. The observation group’s was significantly higher than that of the control group,and the difference was significant( P < 0. 05). The beep recovery of the observation group,the time,duration of defecation,and duration of recovery of exhausted air were all significantly shorter than those of the control group( P < 0. 05). After treatment,the levels of serum IL-6,IL-8,and TNF-α were significantly increased in the observation group. Lower than the control group,the difference was significant( P < 0. 05). Conclusion: Dachengqi Decoction combined with octreotide in the treatment of early inflammatory bowel obstruction after abdominal surgery promotes the remission of clinical symptoms,improves the clinical efficacy,reduces the body’s inflammatory response,and has good safety.

关 键 词：大承气汤 奥曲肽 早期炎性肠梗阻 

分 类 号：R574.2[医药卫生—消化系统]