美沙拉秦联合肠胃宁治疗溃疡性结肠炎疗效及对TGF-β1、IGF-1的影响  

The curative effect of the salad oxazine combined with Chang weining in treating ulcerative colitis and the influences on TGF-β and IGF-1

作　　者：沈秉正[1] 祝成亮[2] 胡振夏 李丹[1] 王娜[1] 陈莹[1] 李景[1] 喻研[3] Shen Bingzheng;Zhu Chengliang;Hu Zhenxia;Li Dan;Wang Na;Chen Ying;Li Jing;Yu Yan(Department of Pharmacy,Renmin Hospital of Wuhan University,Wuhan 430060,China;Department of Clinical Laboratory,Renmin Hospital of Wuhan University,Wuhan 430060,China;Department of Gastroenterology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 43030,China)

机构地区：[1]武汉大学人民医院药学部,430060 [2]武汉大学人民医院检验科,430060 [3]华中科技大学同济医学院附属同济医院消化内科,430030

出　　处：《中华结直肠疾病电子杂志》2019年第2期131-134,共4页Chinese Journal of Colorectal Diseases(Electronic Edition)

基　　金：国家自然科学基金资助项目(No.31700086);病毒学国家重点实验室开放研究基金资助项目(No.2016KF002)

摘　　要：目的探究美沙拉秦联合肠胃宁治疗初发型溃疡性结肠炎疗效及对患者血清细胞因子TGF-β1、IGF-1水平的影响。方法选取来自武汉大学人民医院消化内科就诊并接受治疗的初发型溃疡性结肠炎患者44例,单药治疗组20例仅口服美沙拉秦,联合用药组24例口服美沙拉秦及肠胃宁,对比两组患者临床疗效;选取16例健康人为正常对照组,检测并比较患者治疗前后血清细胞因TGF-β1及IGF-1水平。结果联合用药组经过治疗后总有效率(79.17%)高于单药治疗组(50.00%),差异具有统计学意义(χ~2=4.13,P=0.04)。正常对照组TGF-β1及IGF-1水平分别为(108.50±18.99)ng/L和(255.25±17.41)ng/L;经药物治疗后,联合用药组[(92.46±16.76)ng/L、(221.25±11.56)ng/L]比单药治疗组[(79.45±14.44 ng/L),(181.80±12.12 ng/L)]变化更显著。与治疗前比较,两组患者TGF-β1及IGF-1水平均升高,差异具有统计学意义(单一药物组:t=-4.16,P=0.001;t=-14.22,P=0.000)(联合用药组:t=-8.49,P=0.000;t=-26.7,P=0.000);与单药治疗组相比,治疗后联合用药组患者细胞因子TGF-β1及IGF-1水平升高更显著,差异具有统计学意义(t=2.02,P=0.01;t=2.02,P <0.001)。结论将美沙拉秦与肠胃宁联用能够提高总有效率,患者血清TGF-β1及IGF-1含量更接近正常对照组。Objective To explore the curative effects and influences of the serum cytokines level in patients with UC after the medication treatment combined salad oxazine with Chang weining. Methods Selecting forty-four patients with UC who came to Renmin Hospital of Wuhan University and accepted medication treatment. Twenty patients were only treated with salad oxazine and other twenty-four patients were treated with salad oxazine and Chang weining, then clinical efficacy was compared between the two groups. In addition, sixteen healthy people were chosen as normal control group, and the serum cytokine level of TGF-β and IGF-1 in two groups were measured before and after treatment with medications. Results After treatments, the total efficiency of combination group (79.17%) was higher than that of single drug treatment group (50.00%), and the difference presented statistically significant (χ^2=4.13, P=0.04). The levels of TGF-β1 and IGF-1 in the normal control group were (108.50±18.99) ng/L and (255.25±17.41) ng/L, respectively. After treatment, the combined drug treatment group [(92.46±16.76) ng/L,(221.25±11.56) ng/ L] presented more significant changes than single drug treatment group [(79.45±14.44) ng/L,(181.80±12.12) ng/L]. Compared with the of serum cytokine level before treatment, both TGF-β and IGF-1 levels in two groups were increased, and the difference was statistically significant (single drug treatment group: t=-4.16, P=0.001;t=-14.22, P=0.000)(combined drug treatment group: t=-8.49, P=0.000;t=-26.7, P=0.000). Compared with the single drug treatment group, the level of cytokine in patients with combined drug treatment group was significantly higher, and the difference was statistically significant (t=2.02, P=0.01;t=2.02, P < 0.001). Conclusions The total effective rate was increased by the combination of salad oxazine and Chang weining, and the serum cytokine level of TGF-β1 and IGF-1 of combination group were closer to the normal control group.

关 键 词：溃疡性结肠炎 转化生长因子Β1 胰岛素样生长因子Ⅰ 联合用药 疗效 

分 类 号：R574.62[医药卫生—消化系统]