新型角膜内皮镜SP-1P检测中央角膜厚度的临床应用  

Application of new corneal endoscope SP-1P in the measurement of central corneal thickness

作　　者：任胜卫 庞辰久 孙飒 杨凯丽 代丽娟 孟志红 鲁传琴 REN Sheng-Wei;PANG Chen-Jiu;SUN Sa;YANG Kai-Li;DAI Li-Juan;MENG Zhi-Hong;LU Chuan-Qin(Henan Eye Institute & Henan Eye Hospital,Henan Provincial People’s Hospital,People’s Hospital of Zhengzhou University,Zhengzhou 450003,Henan Province,China)

机构地区：[1]河南省眼科研究所河南省立眼科医院河南省人民医院郑州大学人民医院,河南省郑州市450003

出　　处：《眼科新进展》2019年第4期336-339,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金青年科学基金项目(编号:81200664);河南省自然科学基金(编号:182300410362);河南省科技厅基础与前沿项目(编号:162300410235)~~

摘　　要：目的研究角膜内皮镜SP-1P测量中央角膜厚度(central corneal thickness,CCT)的重复性,以及与A型超声角膜测厚仪(A超)和眼前节光学相干断层扫描仪(anterior segment optical coherence tomography,AS-OCT)检测CCT的一致性。方法前瞻性临床研究。收集2017年8月至10月在河南省眼科研究所准分子激光治疗中心矫正近视的患者114例(均纳入右眼),年龄为(22.14±4.83)岁,采用角膜内皮镜SP-1P连续测量3次CCT,同时通过AS-OCT和A超分别测量CCT,测量结果采用方差分析进行比较,进一步应用Bland-Altman法对一致性进行分析。结果角膜内皮镜SP-1P 3次测得的CCT值分别为(521.33±27.90)μm、(521.70±27.83)μm、(521.69±27.69)μm,差异无统计学意义(F=0.728,P=0.395);Bland-Altman分析结果显示,3次测量间的差值均至少95.6%的点在95%的一致性界限内。A超及AS-OCT测得的CCT值分别为(544.50±30.48)μm和(520.75±28.62)μm,其中角膜内皮镜SP-1P和AS-OCT测得的CCT值均较A超所测CCT值偏低,差异均具有统计学意义(均为P<0.001);而角膜内皮镜SP-1P和AS-OCT测量结果相比,差异无统计学意义(P=0.162)。结论角膜内皮镜SP-1P测量CCT具有良好的重复性和稳定性,角膜内皮镜SP-1P和AS-OCT具有同等的准确性及良好的一致性,可以相互替代;但二者测得的CCT值均较A超偏低。Objective To investigate the repeatability of a new corneal endoscope SP-1P for central corneal thickness (CCT) measurement and further to analyze the consistency of CCT measured by corneal endoscope SP-1P,type-A ultrasonic corneal thickness gauge (A ultrasound) and anterior segment optical coherence tomography (AS-OCT). Methods A retrospective clinical study was performed in Henan eye institute ophthalmic excimer laser treatment center from August to October 2017.A total of 114 patients (all right eyes) aged (22.14±4.83)years old for correction of myopia were included in the current study.The CCT values of individuals were measured three times by corneal endoscope SP-1P,and were also measured by A ultrasound and AS-OCT,respectively.Analysis of variance was used to evaluate the difference,and Bland-Altman method was used to analyze the consistency. Results The CCT values of three repeated corneal endoscope SP-1P measurements were (521.33±27.90)μm,(521.70±27.83)μm and (521.69±27.69)μm,respectively.The difference was not statistically significant among different measured methods (F=0.728, P=0.395).The analysis of Bland-Altman showed that at least 95.6% of the differences among the three repeated measurements were within the 95% consistency limit.The CCT values measured by A ultrasound and AS-OCT were (544.50±30.48)μm and (520.75±28.62)μm,respectively.The CCT values measured by AS-OCT and corneal endoscope SP-1P were lower as comparison with measured by A ultrasound,and the differences were statistically significant (all P<0.001),but no statistically difference was obtained between the CCT values measured by AS-OCT and corneal endoscope SP-1P(P=0.162). Conclusion By using corneal endoscope SP-1P,the measurement of CCT had a good repeatability and stability.Furthermore,corneal endoscope SP-1P and AS-OCT have a similar accuracy and good consistency,but the CCT values were lower measured by SP-1P and AS-OCT than measured by A-ultrasound.

关 键 词：中央角膜厚度 A型超声角膜测厚仪 角膜内皮镜 SP-1P 眼前节光学相干断层扫描仪 

分 类 号：R778.1[医药卫生—眼科]