不同临床背景下角膜新生血管发生机制的研究进展  

Progress on the mechanisms of corneal neovascularization in different clinical backgrounds

作　　者：陈鹤 陆晓和[1] CHEN He;LU Xiao-He(Department of Ophthalmology,Zhujiang Hospital of Southern Medical University,Guangzhou 510280,Guangdong Province,China)

机构地区：[1]南方医科大学珠江医院眼科,广东省广州市510280

出　　处：《眼科新进展》2019年第4期394-397,共4页Recent Advances in Ophthalmology

摘　　要：角膜新生血管是一种常见的病理改变,它可在不同的临床背景下发生,破坏角膜免疫赦免、加剧炎症反应、损害视功能。在不同的疾病中,导致角膜新生血管形成的主要因素不同,例如角膜移植中的宿主免疫反应、角膜缘干细胞缺乏中干细胞的维持和分化、接触镜相关眼病中的缺氧、单纯疱疹角膜炎中的病毒感染。探究和理解角膜新生血管在不同临床背景下的发生机制将有助于发展更有针对性的预防和治疗措施。本文对几种主要疾病中角膜新生血管发生机制的研究进展进行综述。Corneal neovascularization (CNV) is a common pathology and occurs in different corneal diseases.It can breach corneal immune privilege,accelerate inflammation and compromise visual acuity.The leading factor that causes CNV is different in various diseases,for example,the host’s immune response in corneal transplantation,the maintainability and differentiation of stem cells in limbal stem cell deficiency,hypoxia in contact lens-related disease,virus infection in herpes simplex keratitis.Exploration and understanding of the mechanisms of CNV in different diseases will help us develop more targeted measures for prevention and treatment.This article aims to review the mechanisms of CNV in several main diseases.

关 键 词：新生血管性眼病 角膜新生血管 角膜移植 角膜缘干细胞缺乏 角膜接触镜相关眼病 单纯疱疹病毒性角膜炎 

分 类 号：R772.2[医药卫生—眼科]