59例药源性胰腺炎文献分析  

Literature analysis of 59 cases of drug-induced pancreatitis

作　　者：张许[1] 党和勤[1] 刘燕琳[1] 陈文文[1] ZHANG Xu;DANG Heqin;LIU Yanlin;CHEN Wenwen(Department of Pharmacy,Affiliated Hospital of Taishan Medical University,Taian 271000,China)

机构地区：[1]泰山医学院附属医院药剂科,山东泰安271000

出　　处：《药学研究》2019年第3期175-178,共4页Journal of Pharmaceutical Research

基　　金：山东省医药卫生科技发展计划项目(No.2018WS120);泰山医学院附属医院苗圃计划(No.2014QN05)

摘　　要：目的探讨药源性胰腺炎发生的特点,为临床安全用药提供参考。方法检索中国期刊全文数据库1981～2018年报道的药源性胰腺炎个案病例文献,并对其进行汇总分析。结果共纳入56篇文献,59例病例。发生药源性胰腺炎较多的药物为抗肿瘤药物(28.81%)、抗感染药物(23.73%)及激素相关性药物(15.25%);10岁以下患者构成比最高(22.03%)。59例患者中,31例发生在给药1周以内(52.54%),54例患者治愈(91.53%),4例患者死亡(6.78%),情况不明患者1例(1.69%)。结论左旋门冬酰胺酶、替加环素、利福平及泼尼松等易诱发药源性胰腺炎,临床应用以上药物时需密切关注患者症状。Objective To investigate characteristics of drug-induced pancreatitis,supplying evidences for rational drug use in clinical practice. Methods Related literatures of drug-induced pancreatitis published on CNKI database from 1987 to 2018 were collected and analyzed. Results A total of 56 articles were included,involving 59 cases.Anticancer drugs,anti-infective drugs and hormone drugs were associated with high occurrence rate (28.81%,23.73% and 15.25%,respectively).Patients aged less than 10 years old appear to have highest occurrence rate (22%).Of 59 cases,31cases( 52.54%) occurred within one week,54 cases (91.53%) were cured,4 cases (6.78%) were died and 1 cases (1.69%) was unclear. Conclusion L-asparaginase,tegacycline,rifampicin and prednisone can easily induce drug-induced pancreatitis,so patients′ symptoms should be paid close attention to in the clinical application of the above drugs.

关 键 词：药源性胰腺炎 文献分析 药品不良反应 

分 类 号：R576[医药卫生—消化系统]