阿尔茨海默病患者认知功能与其血清IL-6、hs-CRP、Hcy、Cys C水平相关性分析  

Analysis of Correlation between Cognitive Function and Levels of IL-6,hs-CRP,Hey and Cys C in Patients with Senile Dementia

作　　者：郭敏[1] 金迪[1] 王培福[1] 李继来[1] GUO Min;JIN Di;WANG Pei-fu(Department of Neurology,Aerospace Center Hospital,Beijing 100049)

机构地区：[1]航天中心医院神经内科,北京100049

出　　处：《医学临床研究》2019年第2期280-281,284,共3页Journal of Clinical Research

摘　　要：【目的】通过检测阿尔兹海默病(AD)患者血清白介素-6(IL-6)、高敏C-反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)、胱抑素C(CysC)水平,探讨其与AD患者认知功能的相关性。【方法】选取2014年6月至2017年10月本院收治的AD患者106例,按照简易智能精神状态量表(MMSE)评分分为AD组59例,轻度认知功能障碍(MCI)组47例,另外选取同期于本院体检健康及受教育程度匹配者40例为对照组,比较各组之间血清指标水平,采用Logistic回归分析AD患者患病风险与血清指标的关系。【结果】Hey、hs-CRP水平:AD组〉MCI组〉对照组(P<0.05);Cys C水平:AD组<MCI组<对照组(P<0.05);IL-6水平:AD组>MCI组〉对照组(P>0.05)。AD患者血清IL-6、hs-CRP、Hcy、Cys C水平与MMSE评分无显著相关性(P>0.05),AD患病风险与低叶酸、高hs-CRP、高Hey水平相关.【结论】AD患者认知功能与血清IL-6、hs-CRP、Hcy、CysC水平无明显相关性;低叶酸、高hs-CRP、高Hey水平可能増加AD患病风险。Cys C水平可能为AD患者认知功能障碍的保护因素。【Objective】This aim was to investigate the relationship between cognitive function and serum levels of interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP),homocysteine(Hey)and Cys C in patients with senile dementia(Alzheimers disease).【Methods】a total of 106 patients with senile demenlia admitted to our hospital from June 2014 to October 2017 were selected in lhe study.According to MMSE score,patients were divided into two groups:Alzheimers disease(AD,n=59)and mild cognitive impairment(MCI,n=47).Meanwhile,40 healthy subjects with matched health and education status in the same period were selected as the control group.Logistic regression analysis was used to analyze the relationship between the risk of dementia and serum indexes.【Results】The levels of Hey and hs-CRP were AD group>MCI group>the control group(P<0.05).Cys C level order was AD group>MCI group>the control group(P<0.05).The level of IL-6 seemed to show AD group,MCI group>the control group.However,the differences were not statistically significant(P<0.05).The serum levels of IL-6,hs-CRP,Hey and Cys C in AD patients were not significantly correlated with MMSE scores(P>0.05).The prevalence of AD is associated with levels of low folate,high hs-('RP and high Hey.【Conclusion】The results show that there is no significant correlation between cognitive function and serum levels of IL-6,hs-CRP,Hey and Cys C in patients with Alzheimers disease.Low folate,high Hey levels and high hs-CRP levels may increase the risk of AD by some mechanism.Cys C may be protective factors of cognilive impairment in AD.

关 键 词：阿尔茨海默病/病理生理学 认知障碍 细胞因子类 

分 类 号：R742[医药卫生—神经病学与精神病学]