微创腹腔镜与传统开腹肝切除术治疗肝癌的效果比较  

Clinical effects minimally invasive laparoscopy and traditional open hepatectomy on the patients with liver cancer

作　　者：苏华斌[1] 张辉[1] 范少峰[1] 马成慧 Su Huabin;Zhang Hui;Fan Shaofeng;Ma Chenghui(Department of neral Surgery,the Eighth People's Hospital of Guangzhou ,Guangzhou 510440,China)

机构地区：[1]广东省广州市第八人民医院普外科,510440

出　　处：《临床医学》2018年第12期39-41,共3页Clinical Medicine

摘　　要：目的探讨微创腹腔镜与传统开腹肝切除术治疗肝癌的效果。方法选取2016年3月至2017年2月80例肝癌患者,按照随机数字表法均分为观察组和对照组,每组40例。对照组采取传统开腹肝切除术治疗,观察组采取微创腹腔镜肝切除治疗。观察手术相关情况、血清指标相关情况、1年生存率、局部复发率、转移率发生情况。结果两组手术时间比较,差异未见统计学意义(P> 0. 05),观察组出血量、排气时间、下床活动时间、引流管留置时间、进食时间、住院时间均低于对照组(P <0. 05);两组患者治疗后白细胞介素-6(IL-6)、降钙素原(PCT)、基质金属蛋白酶-13(MMP-13)、细胞间黏附分子-1(ICAM-1)水平均升高,均高于治疗前(P <0. 05),观察组治疗后IL-6、PCT、MMP-13、ICAM-1水平均低于对照组(P <0. 05);两组1年生存率、局部复发率、转移率比较,差异未见统计学意义(P> 0. 05)。结论与传统开腹肝切除术治疗肝癌比较,微创腹腔镜切除术治疗效果更好,患者手术相关情况改善较好,而且患者IL-6、PCT、MMP-13、ICAM-1水平控制较好,但两组患者手术时间及术后1年生存率、局部复发率、转移率相差不明显。Objective To investigate the clinical effects minimally invasive laparoscopy andtraditional open hepatectomy on the patients with liver cancer.Methods Eighty patients with liver cancerwere randomly divided into observation group(40 cases)and control group(40 cases).The control groupwas given traditional open hepatectomy,and the observation group was given minimally invasivelaparoscopic.The operation related indexes,serum indexes,1 year survival rate,local reccurrence rate,metastasis rate was observed.The clinical effects were observed.Results There was no significantdifference in the time of operation(P>0.05);The amount of bleeding,exhaust time,the time of the nextbed,the time of the drainage tube,the time of feeding and the hospital stay for the observation group werelower than those of the control group(P<0.05).The levels of IL-6,PCT,MMP-13,ICAM-1 aftertreatment of the two groups were higher than those before treatment(P<0.05).The levels of IL-6,PCT,MMP-13,ICAM-1 after treatment of the observation group were lower than those of the control group(P<0.05).There was no significant difference in the 1 year survival rate,local recurrence rate,transfer ratebetween the two groups(P>0.05).Conclusions It has good clinical effects for the patients with livercancer by minimally invasive laparoscopy,which can control the levels of IL-6,PCT,MMP-13,ICAM-1,with no obvious difference in the 1 year survival rate,local recurrence rate,or transfer rate.

关 键 词：微创腹腔镜 传统开腹肝切除术 肝癌 

分 类 号：R735.7[医药卫生—肿瘤]